About: Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling

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About: Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aspartátové proteasy sekretované C. albicans (Sap2p), C. tropicalis (Sapt1p) a C. parapsilosis (Sapp1p) byly purifikovány a testovány se sérií různě modifikovaných peptidomimetických inhibitorů. Vybrané látky inhibovaly proteasy v nanomolárních koncentracích. Srovnání primárních struktur a homologní modelování struktury (Sapp1p) se známými strukturami Sapt1p a komplexu inhibitoru se Sap2p umožnily identifikovat strukturní prvky odpovědné za rozdílnou inhibici jednotlivých proteas. (cs) Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition. Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition. (en)
Title	Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování (cs) Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling (en)
skos:prefLabel	Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování (cs) Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling (en)
skos:notation	RIV/61388963:_____/06:00043419!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany	1247;1254
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/04/0432), P(LC531), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Pavlíčková, Libuše Dolejší, Elena Hradílek, Martin Pichová, Iva Hrušková, Olga
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	502016
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/06:00043419
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Candida albicans; Candida parapsilosis; Candida inhibitors; secreted aspartic protease (en)
http://linked.open.../riv/klicoveSlovo	Candida parapsilosis secreted aspartic protease Candida albicans Candida inhibitors
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[2C6C8438B73F]
http://linked.open...i/riv/nazevZdroje	Biological Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre on molecular biology and physiology of yeast communities Study of the role of different isoenzymes of aspartic proteases in the virulence of Candida spp.
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	387
http://linked.open...iv/tvurceVysledku	Pichová, Iva Hrušková, Olga Pavlíčková, Libuše Majer, F. Majer, P. Hradilek, Martin Dolejší, Elena
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1431-6730
number of pages	8 (xsd:int)

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