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Description
| - V této studii jsme připravili sérii thyminových, 5-ethyluracilových a 5-fluoruracilových acyklických nukleosidových fosfonátů nesoucích vodík, hydroxymethyl, fluormethyl, methoxymethyl, azidomethyl, aminomethyl a (trimethylammonio)methyl v postraním řetězci jako potenciální inhibitory thymidinfosforylasy. Zatímco 5-fluoruracilové deriváty ukazují nevýznamný inhibiční účinek, thyminové a 5-ethyluracilové sloučeniny s řadou vybraných substituentů v postraním řetězci mají významnou inhibiční účinnost vůči thymidinfosforylase z potkaního spontanního T-buněčného lymfomu. (cs)
- In this study we synthesized a series of thymine, 5-ethyluracil and 5-fluorouracil acyclic nucleoside phosphonates bearing hydrogen, hydroxymethyl, fluoromethyl, methoxymethyl, azidomethyl, aminomethyl and (trimethylammonio)methyl group in side chain as potent inhibitors of thymidine phosphorylase. While the 5-fluorouracil derivatives exhibit a marginal inhibitory effect, thymine and 5-ethyluracil compounds with a number described substituents in side chains possess considerable inhibitory potency toward thymidine phosphorylase from rat spontaneous T-cell lymphoma.
- In this study we synthesized a series of thymine, 5-ethyluracil and 5-fluorouracil acyclic nucleoside phosphonates bearing hydrogen, hydroxymethyl, fluoromethyl, methoxymethyl, azidomethyl, aminomethyl and (trimethylammonio)methyl group in side chain as potent inhibitors of thymidine phosphorylase. While the 5-fluorouracil derivatives exhibit a marginal inhibitory effect, thymine and 5-ethyluracil compounds with a number described substituents in side chains possess considerable inhibitory potency toward thymidine phosphorylase from rat spontaneous T-cell lymphoma. (en)
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Title
| - Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
- Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
- Syntézy 1-[2-(fospfonomethoxy)propyl] derivátů modifikovaných bázemi a na postraním řetězci jako potenciálních inibitorů thymidinfosforylasy (PD-ECGF) z SD-lymfomu (cs)
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skos:prefLabel
| - Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
- Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
- Syntézy 1-[2-(fospfonomethoxy)propyl] derivátů modifikovaných bázemi a na postraním řetězci jako potenciálních inibitorů thymidinfosforylasy (PD-ECGF) z SD-lymfomu (cs)
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skos:notation
| - RIV/61388963:_____/06:00039427!RIV07-AV0-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA203/03/0089), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/06:00039427
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acyclic nucleoside phosphonates; thymidine phosphorylase; fluorination; pyrimidines (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Collection of Czechoslovak Chemical Communications
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Holý, Antonín
- Pohl, Radek
- Votruba, Ivan
- Pomeisl, Karel
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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