About: Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma     Goto   Sponge   NotDistinct   Permalink

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  • V této studii jsme připravili sérii thyminových, 5-ethyluracilových a 5-fluoruracilových acyklických nukleosidových fosfonátů nesoucích vodík, hydroxymethyl, fluormethyl, methoxymethyl, azidomethyl, aminomethyl a (trimethylammonio)methyl v postraním řetězci jako potenciální inhibitory thymidinfosforylasy. Zatímco 5-fluoruracilové deriváty ukazují nevýznamný inhibiční účinek, thyminové a 5-ethyluracilové sloučeniny s řadou vybraných substituentů v postraním řetězci mají významnou inhibiční účinnost vůči thymidinfosforylase z potkaního spontanního T-buněčného lymfomu. (cs)
  • In this study we synthesized a series of thymine, 5-ethyluracil and 5-fluorouracil acyclic nucleoside phosphonates bearing hydrogen, hydroxymethyl, fluoromethyl, methoxymethyl, azidomethyl, aminomethyl and (trimethylammonio)methyl group in side chain as potent inhibitors of thymidine phosphorylase. While the 5-fluorouracil derivatives exhibit a marginal inhibitory effect, thymine and 5-ethyluracil compounds with a number described substituents in side chains possess considerable inhibitory potency toward thymidine phosphorylase from rat spontaneous T-cell lymphoma.
  • In this study we synthesized a series of thymine, 5-ethyluracil and 5-fluorouracil acyclic nucleoside phosphonates bearing hydrogen, hydroxymethyl, fluoromethyl, methoxymethyl, azidomethyl, aminomethyl and (trimethylammonio)methyl group in side chain as potent inhibitors of thymidine phosphorylase. While the 5-fluorouracil derivatives exhibit a marginal inhibitory effect, thymine and 5-ethyluracil compounds with a number described substituents in side chains possess considerable inhibitory potency toward thymidine phosphorylase from rat spontaneous T-cell lymphoma. (en)
Title
  • Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
  • Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
  • Syntézy 1-[2-(fospfonomethoxy)propyl] derivátů modifikovaných bázemi a na postraním řetězci jako potenciálních inibitorů thymidinfosforylasy (PD-ECGF) z SD-lymfomu (cs)
skos:prefLabel
  • Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
  • Syntheses of base and side-chain modified pyrimidine 1-[2-(phosphonomethoxy)propyl] derivatives as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma (en)
  • Syntézy 1-[2-(fospfonomethoxy)propyl] derivátů modifikovaných bázemi a na postraním řetězci jako potenciálních inibitorů thymidinfosforylasy (PD-ECGF) z SD-lymfomu (cs)
skos:notation
  • RIV/61388963:_____/06:00039427!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 595;624
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/03/0089), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 502766
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00039427
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonates; thymidine phosphorylase; fluorination; pyrimidines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [9B68292551E2]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 71
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Pohl, Radek
  • Votruba, Ivan
  • Pomeisl, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 0010-0765
number of pages
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