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Description
  • The series of N4-alkyl derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-ethylcytosine was prepared from the corresponding 5-ethyl-4-methoxypyrimidin-2-(1H )-one intermediates by the action of primary amines. Sonogashira coupling was used for the preparation of 5-ethynyl HPMPC. None of the synthesized compounds exhibited antiviral activity in vitro
  • The series of N4-alkyl derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-ethylcytosine was prepared from the corresponding 5-ethyl-4-methoxypyrimidin-2-(1H )-one intermediates by the action of primary amines. Sonogashira coupling was used for the preparation of 5-ethynyl HPMPC. None of the synthesized compounds exhibited antiviral activity in vitro (en)
  • Série N4-alkylderivátů (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-ethylcytosinu byla připravena z příslušných 5-ethyl-4-methoxypyrimidin-2-(1H )-onových intermediátů reakcí s primárními aminy. Pro přípravu 5-ethynyl-HPMPC byl využit Sonogashirův coupling. Žádná ze syntetizovaných látek nevykazovala protivirovou aktivitu in vitro. (cs)
Title
  • Preparation of C-5 Substituted Cidofovir Derivatives
  • Preparation of C-5 Substituted Cidofovir Derivatives (en)
  • Příprava C-5 substituovaných derivátů cidofoviru (cs)
skos:prefLabel
  • Preparation of C-5 Substituted Cidofovir Derivatives
  • Preparation of C-5 Substituted Cidofovir Derivatives (en)
  • Příprava C-5 substituovaných derivátů cidofoviru (cs)
skos:notation
  • RIV/61388963:_____/06:00039394!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 579;594
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 494238
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00039394
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • C-5 alkylation; N4-alkylcytosines; sonogashira coupling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D3239A0BECA6]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 71
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Krečmerová, Marcela
  • Masojídková, Milena
http://linked.open...n/vavai/riv/zamer
issn
  • 0010-0765
number of pages
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