About: Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines     Goto   Sponge   NotDistinct   Permalink

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Description
  • Novel 1,3-bis[(diisopropoxyphosphoryl)methoxy]propan-2-yl N9-substituted derivatives of purines and N1-substituted derivatives of pyrimidines were prepared by the alkylation of basic nucleobases (6-chloropurine and 2-amino-6-chloropurine), their conversion, and subsequent, deprotection of isopropyl groups of phosphonates. No biological activity was found so far.
  • Novel 1,3-bis[(diisopropoxyphosphoryl)methoxy]propan-2-yl N9-substituted derivatives of purines and N1-substituted derivatives of pyrimidines were prepared by the alkylation of basic nucleobases (6-chloropurine and 2-amino-6-chloropurine), their conversion, and subsequent, deprotection of isopropyl groups of phosphonates. No biological activity was found so far. (en)
  • Nové 1,3-bis[(diisopropoxyfosforyl)methoxy]propan-2-yl N9-substituované deriváty purinů a N1-substituovaných pyrimidinů byly připraveny alkylací základních nukleobazí (6-chlorpurin a 2-amino-6-chlorpurin), jejich konverzí a následným odchráněním isopropylových skupin esterů fosfonátů.U získaných volných fosfonových kyselin nebyla dosud zjištěna žádná biologická aktivita. (cs)
Title
  • Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines
  • Bifunkční acyklické nukleosidové fosfonáty: 1. Symetrické 1,3-bis[(phosphonomethoxy)propane-2-yl] deriváty purinů a pyrimidinů (cs)
  • Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines (en)
skos:prefLabel
  • Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines
  • Bifunkční acyklické nukleosidové fosfonáty: 1. Symetrické 1,3-bis[(phosphonomethoxy)propane-2-yl] deriváty purinů a pyrimidinů (cs)
  • Bifunctional acyclic nucleoside phosphonates. 1. Symmetrical 1,3-bis[phosphonomethoxy)propan-2-yl] derivatives of purines and pyrimidines (en)
skos:notation
  • RIV/61388963:_____/06:00039392!RIV07-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 543;566
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(1QS400550501), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 466893
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/06:00039392
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonates; ANP; phosphonomethyl ethers; biphosphonates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [DC573E23BBEF]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 71
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Pohl, Radek
  • Masojídková, Milena
  • Vrbovská, Silvie
http://linked.open...n/vavai/riv/zamer
issn
  • 0010-0765
number of pages
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