About: Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	O-(Carboxymethyl)oximes 1 and 2 derived from two epimeric 5beta-pregnanolones (3beta- hydroxy-5beta-pregnan-20-one and 3alpha-hydroxy-5beta-pregnan-20-one) in position 19 were prepared. Two synthetic routes were employed, both using protection of the 20-keto group after reduction into the (20R)-alcohol in the form of acetate. Both haptens, i.e., (19E)-3beta- and -3alpha-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-(carboxymethyl)oxime], were designed for the development of immunoassays of the corresponding parent neuroactive steroids. O-(Carboxymethyl)oximes 1 and 2 derived from two epimeric 5beta-pregnanolones (3beta- hydroxy-5beta-pregnan-20-one and 3alpha-hydroxy-5beta-pregnan-20-one) in position 19 were prepared. Two synthetic routes were employed, both using protection of the 20-keto group after reduction into the (20R)-alcohol in the form of acetate. Both haptens, i.e., (19E)-3beta- and -3alpha-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-(carboxymethyl)oxime], were designed for the development of immunoassays of the corresponding parent neuroactive steroids. (en) Byly připraveny O-(karboxymethyl)oximy 1 a 2, odvozené od dvou epimerických 5beta-pregnanolonů v poloze 19. Byly vypracovány dva syntetické přístupy využívající chránění 20-keto skupiny po redukci na (20R)-alkohol ve formě acetátu. Oba hapteny, tj. (19E)-3beta- a -3alfa-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-karboxymethyl)ixim], byly navrženy pro vývoj imunostanovení matečných neuroaktivních steroidů. (cs)
Title	Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone Syntézy 19-[O-(karboxymethyl)oximových haptenů od epipregnanolonu a pregnanolonu (cs) Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone (en)
skos:prefLabel	Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone Syntézy 19-[O-(karboxymethyl)oximových haptenů od epipregnanolonu a pregnanolonu (cs) Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone (en)
skos:notation	RIV/61388963:_____/06:00030752!RIV06-GA0-61388963
http://linked.open.../vavai/riv/strany	120;128
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/04/0123), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Černý, Ivan Pouzar, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	502769
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/06:00030752
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	synthesis; pregnanolone; O-(carboxymethyl)oxime; steroids (en)
http://linked.open.../riv/klicoveSlovo	steroids synthesis O-(carboxymethyl)oxime pregnanolone
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5F426DE544FA]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Haptens for immunoassays of neuroactive steroids of pregnanolone type
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	71
http://linked.open...iv/tvurceVysledku	Pouzar, Vladimír Černý, Ivan Hill, M. Hampl, R. Havlíková, H.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0039-128X
number of pages	9 (xsd:int)

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