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Description
  • Almost 20years after the broad antiviral activity spectrum of the first acyclic nucleoside phosphonates was described, several of these compounds have become important therapies for DNA virus and retrovirus infections. Here, we review the discovery and development of acyclic nucleoside phosphonates, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, adefovir for the treatment of hepatitis B and tenofovir for the treatment of AIDS and the prevention of HIV infections.
  • Almost 20years after the broad antiviral activity spectrum of the first acyclic nucleoside phosphonates was described, several of these compounds have become important therapies for DNA virus and retrovirus infections. Here, we review the discovery and development of acyclic nucleoside phosphonates, focusing on cidofovir and its potential in the treatment of various herpes-, papilloma-, polyoma-, adeno- and pox-virus infections, adefovir for the treatment of hepatitis B and tenofovir for the treatment of AIDS and the prevention of HIV infections. (en)
  • Téměř před 20 lety jsme poprvé popsali novou skupinu látek s vysokým účinkem proti DNA virům a retrovirům. V tomto referátu je popsána historie jejich objevu a vývoje až k léčivům, se zvláštním zřetelem na cidofovir jako důležitý lék proti poxvirovým infekcím včetně pravých neštovic (potenciálně zneužitelných bioteroristy), adefovir, určený pro léčení hepatitity B a tenofovir - velice účinný a málo toxický lék, používaný masově jako důležitá součást terapie AIDSu. (cs)
Title
  • Acyclic nucleoside phosphonates: A key class of antiviral drugs
  • Acyklické nukleosidfosfonáty - klíčová skupina protivirových léčiv (cs)
  • Acyclic nucleoside phosphonates: A key class of antiviral drugs (en)
skos:prefLabel
  • Acyclic nucleoside phosphonates: A key class of antiviral drugs
  • Acyklické nukleosidfosfonáty - klíčová skupina protivirových léčiv (cs)
  • Acyclic nucleoside phosphonates: A key class of antiviral drugs (en)
skos:notation
  • RIV/61388963:_____/05:00023628!RIV06-AV0-61388963
http://linked.open.../vavai/riv/strany
  • 928;940
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika
  • 13
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 511337
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/05:00023628
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tenofovir; adefovir; cidofovir (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [F8855495680A]
http://linked.open...i/riv/nazevZdroje
  • Nature Reviews Drug Discovery
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 4
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • De Clercq, E.
http://linked.open...n/vavai/riv/zamer
issn
  • 1474-1776
number of pages
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