About: Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl]counterparts     Goto   Sponge   NotDistinct   Permalink

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Description
  • A novel method of transformation of HOCH2 group to FCH2 was successfully applied to the preparation of fluorine-containing pyrimidine acyclic nucleoside phosphonates (FPMP compounds) such as (S)- and (R)- 1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine (FPMPT). Novel pyrimidine acyclic nucleoside phosphonates were investigated as inhibitors of thymidine phosphorylase.
  • A novel method of transformation of HOCH2 group to FCH2 was successfully applied to the preparation of fluorine-containing pyrimidine acyclic nucleoside phosphonates (FPMP compounds) such as (S)- and (R)- 1-[3-fluoro-2-(phosphonomethoxy)-propyl]thymine (FPMPT). Novel pyrimidine acyclic nucleoside phosphonates were investigated as inhibitors of thymidine phosphorylase. (en)
  • Nová metoda přeměny HOCH2 skupiny na FCH2 byla úspěšně použita pro přípravu pyrimidinových acyklických nukleosidových fosfonátů (FPMP sloučenin) takových jako (S)- a (R)- 1-[3-fluor-2-(fosfonomethoxy)-propyl]thyminů (FPMPT) obsahujících fluor. Nové pyrimidinové acyklické nukleosidových fosfonáty byly studovány jako inhibitory thymidinfosforylásy. (cs)
Title
  • Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl]counterparts
  • Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl]counterparts (en)
  • Jednoduchá přeměna thyminových 1-[3-hydroxy-2-(fosfonomethoxy)propyl] derivátů na jejich 1-[3-fluoro-2-(fosfonomethoxy)propyl] protějšky (cs)
skos:prefLabel
  • Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl]counterparts
  • Simple transformation of thymine 1-[3-hydroxy-2-(phosphonomethoxy)propyl] derivatives to their 1-[3-fluoro-2-(phosphonomethoxy)propyl]counterparts (en)
  • Jednoduchá přeměna thyminových 1-[3-hydroxy-2-(fosfonomethoxy)propyl] derivátů na jejich 1-[3-fluoro-2-(fosfonomethoxy)propyl] protějšky (cs)
skos:notation
  • RIV/61388963:_____/05:00023611!RIV06-GA0-61388963
http://linked.open.../vavai/riv/strany
  • 1465;1481
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/03/0089), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 542647
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/05:00023611
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonate; thymidine phosphorylase; pyrimidines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [B21EE0BA1DCE]
http://linked.open...i/riv/nazevZdroje
  • Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 70
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Pohl, Radek
  • Votruba, Ivan
  • Pomeisl, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 0010-0765
number of pages
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