About: Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities

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About: Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nové acyklické nukleosidové fosfonáty s pyrimidinovými bázemi obsahující amino skupinu v poloze C2 a C4 a 2-(fosfonomethoxy)ethoxy nebo (R)-2-(fosfonomethoxy)propoxy skupinu v poloze C6 selektivně inhibují replikaci divokého a lamivudin -resistentního typu viru hepatitidy B. Aktivita nejúčinnějších sloučenin byla srovnatelná s aktivitou adefoviru. (cs) Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B virus. The activity of the most potent compounds was comparable to that of adefovir Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B virus. The activity of the most potent compounds was comparable to that of adefovir (en)
Title	Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities (en) Nová analoga acyklických nukleosidových fosfonátů se silnou aktivitou proti viru hepatitidy B (cs)
skos:prefLabel	Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities (en) Nová analoga acyklických nukleosidových fosfonátů se silnou aktivitou proti viru hepatitidy B (cs)
skos:notation	RIV/61388963:_____/05:00023378!RIV06-AV0-61388963
http://linked.open.../vavai/riv/strany	1177;1180
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS4055109), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Hocková, Dana Holý, Antonín Havlas, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	533319
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/05:00023378
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antivirals; hepatitis B; ANP (en)
http://linked.open.../riv/klicoveSlovo	hepatitis B antivirals ANP
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5E062832D962]
http://linked.open...i/riv/nazevZdroje	Antimicrobial Agents and Chemotherapy
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Acyclic nucleoside phosponates with antineoplastic activity
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Holý, Antonín Hocková, Dana Neyts, J. Havlas, Zdeněk De Clercq, E. Ying, C.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0066-4804
number of pages	4 (xsd:int)

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