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Description
  • Nový typ acyklických nukleosid fosfonátů (ANP) je odvozen od 2,4-diamino-6-hydroxypyrimidinu. Tyto deriváty 6-[2-(fosfonomethoxy)ethoxy]pyrimidinu inhibují replikaci retrovirů a herpesvirů in vitro. Tyto látky jsou považovány za analogy 2,6-diaminopurinu s otevřeným imidazolovým jádrem. Byly připraveny nové deriváty pyrimidinu nesoucí v polohách 4 a 6 chirální substituenty. (cs)
  • A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety.
  • A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety. (en)
Title
  • Synthesis and properties of chiral open-ring acyclic nucleoside bisphosphonates
  • Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem (cs)
  • Synthesis and properties of chiral open-ring acyclic nucleoside bisphosphonates (en)
skos:prefLabel
  • Synthesis and properties of chiral open-ring acyclic nucleoside bisphosphonates
  • Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem (cs)
  • Synthesis and properties of chiral open-ring acyclic nucleoside bisphosphonates (en)
skos:notation
  • RIV/61388963:_____/05:00022900!RIV06-MSM-61388963
http://linked.open.../vavai/riv/strany
  • 395;396
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), Z(AV0Z40550506)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 545717
http://linked.open...ai/riv/idVysledku
  • RIV/61388963:_____/05:00022900
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acyclic nucleoside phosphonate; pyrimidine; antiviral activity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [4FD254E03501]
http://linked.open...v/mistoKonaniAkce
  • Špindlerův Mlýn
http://linked.open...i/riv/mistoVydani
  • Praha
http://linked.open...i/riv/nazevZdroje
  • Chemistry of Nucleic Acid Components
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Masojídková, Milena
  • Doláková, Petra
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Ústav organické chemie a biochemie AV ČR
https://schema.org/isbn
  • 80-86241-25-4
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