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rdf:type
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Description
| - We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide.
- We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide. (en)
- Studovali jsme inhibiční interakci fragmentů propeptidu se zralým kathepsinem H a rekombinantním kathepsinem H, který neobsahuje miniřetězec. Rozdíl v interakci u obou enzymů ukazuje, že v molekule kathepsinu H probíhají strukturní změny indukované během zrání, zejména tvorba miniřetězce. Tyto změny brání účinné inhibici zralého kathepsinu H jeho vlastním propeptidem. (cs)
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Title
| - Activation processing of cathepsin H impairs recognition by its propeptide
- Activation processing of cathepsin H impairs recognition by its propeptide (en)
- Aktivační procesing kathepsinu H brání interakci s propeptidem (cs)
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skos:prefLabel
| - Activation processing of cathepsin H impairs recognition by its propeptide
- Activation processing of cathepsin H impairs recognition by its propeptide (en)
- Aktivační procesing kathepsinu H brání interakci s propeptidem (cs)
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skos:notation
| - RIV/61388963:_____/05:00021256!RIV06-MSM-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GP203/01/D008), P(IAA4055303), P(LC512), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/05:00021256
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - aminopeptidase; cysteine peptidase; inhibition (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Horn, Martin
- Mareš, Michael
- Máša, Martin
- Rulíšek, Lubomír
- Marešová, Lucie
- Baudyš, Miroslav
- Gan-Erdene, T.
- Turk, B.
- Vasiljeva, O.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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