About: Activation processing of cathepsin H impairs recognition by its propeptide

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide. We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide. (en) Studovali jsme inhibiční interakci fragmentů propeptidu se zralým kathepsinem H a rekombinantním kathepsinem H, který neobsahuje miniřetězec. Rozdíl v interakci u obou enzymů ukazuje, že v molekule kathepsinu H probíhají strukturní změny indukované během zrání, zejména tvorba miniřetězce. Tyto změny brání účinné inhibici zralého kathepsinu H jeho vlastním propeptidem. (cs)
Title	Activation processing of cathepsin H impairs recognition by its propeptide Activation processing of cathepsin H impairs recognition by its propeptide (en) Aktivační procesing kathepsinu H brání interakci s propeptidem (cs)
skos:prefLabel	Activation processing of cathepsin H impairs recognition by its propeptide Activation processing of cathepsin H impairs recognition by its propeptide (en) Aktivační procesing kathepsinu H brání interakci s propeptidem (cs)
skos:notation	RIV/61388963:_____/05:00021256!RIV06-MSM-61388963
http://linked.open.../vavai/riv/strany	941;947
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/01/D008), P(IAA4055303), P(LC512), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Rulíšek, Lubomír Baudyš, Miroslav Mareš, Michael Máša, Martin Horn, Martin Marešová, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	511304
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/05:00021256
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aminopeptidase; cysteine peptidase; inhibition (en)
http://linked.open.../riv/klicoveSlovo	inhibition cysteine peptidase aminopeptidase
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[A8CD4286F989]
http://linked.open...i/riv/nazevZdroje	Biological Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for biomolecules and complex molecular systems Design of novel peptidic inhibitors of cysteine and aspartic proteases Modulation of enzymatic activity in cathepsins
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	386
http://linked.open...iv/tvurceVysledku	Horn, Martin Mareš, Michael Máša, Martin Rulíšek, Lubomír Marešová, Lucie Baudyš, Miroslav Gan-Erdene, T. Turk, B. Vasiljeva, O.
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1431-6730
number of pages	7 (xsd:int)

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