About: Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this paper we describe kinetic characterisation of two highly resistant proteases isolated from HIV-positive patients undergoing higly active antiretroviral therapy including protease inhibitors. Kinetic analysis revealed that second-generation PI lopinavir and pseudopeptide inhibitor QF34 retained their subnanomolar potency against both multidrug resistant PR variants In this paper we describe kinetic characterisation of two highly resistant proteases isolated from HIV-positive patients undergoing higly active antiretroviral therapy including protease inhibitors. Kinetic analysis revealed that second-generation PI lopinavir and pseudopeptide inhibitor QF34 retained their subnanomolar potency against both multidrug resistant PR variants (en) V této publikaci popisujeme kinetickou charakterisaci dvou vysoce resistentních proteas isolovaných z HIV-positivních pacientů procházejících vysoce aktivní antiretrovirovou terapií zahrnující proteasové inhibitory. Kinetická analysa prokázala, že lopinavir, inhibitor proteasy druhé generace, a pseudopeptidový inhibitor QF34, si udržují svou subnanomolární aktivitu proti vysoce resistentním variantám proteasy (cs)
Title	Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition Charakterisace mutantních proteas odvozených z HIV-positivních pacientů: enzymová aktivita, vitalita a inhibice (cs) Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition (en)
skos:prefLabel	Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition Charakterisace mutantních proteas odvozených z HIV-positivních pacientů: enzymová aktivita, vitalita a inhibice (cs) Characterisation of mutated proteinases derived from HIV-positive patients: enzime activity, vitality and inhibition (en)
skos:notation	RIV/61388963:_____/04:00100873!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	703;714
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NI6339), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Souček, Milan Prejdová, Jana Konvalinka, Jan Kožíšek, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	557365
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100873
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	enzyme inhibitors;HIV protease;enzyme kinetics (en)
http://linked.open.../riv/klicoveSlovo	enzyme kinetics HIV protease enzyme inhibitors
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8D0EEA41FAD3]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Detection and characterisation of HIV-1 mutants resistant to specific therapy with protease inhibitors: evolution of the resistant species and their interactions with other viral proteins
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Konvalinka, Jan Kožíšek, Milan Prejdová, Jana Souček, Milan Machala, L. Staňková, M. Brůčková, M. Linka, M.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0010-0765
number of pages	11 (xsd:int)

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