About: Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds

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About: Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Synthesis of 2,4-diamino-5-cyano-6-{[(diisopropoxyphosphoryl)methoxy]ethoxy}pyrimid ine was based on the formation of the pyrimidine ring by cyclization followed by modification of the side chain by alkylation. The 5-cyano group was also transformed to a 5-formyl and 5-hydroxymethyl group by reduction. Some derivatives showed pronounced antiretroviral activity Synthesis of 2,4-diamino-5-cyano-6-{[(diisopropoxyphosphoryl)methoxy]ethoxy}pyrimid ine was based on the formation of the pyrimidine ring by cyclization followed by modification of the side chain by alkylation. The 5-cyano group was also transformed to a 5-formyl and 5-hydroxymethyl group by reduction. Some derivatives showed pronounced antiretroviral activity (en) Syntéza a protivirová aktivita 2,4-diamino-5-kyano-6-[2-(fosfonomethoxy)ethoxy]pyrimidinu je zaĺožena na tvorbě pyrimidinového kruhu cyklizací a následující alkylací. 5-kyanoskupina byla dáĺe převedena na formyl a 5-hydroxymethylskupinu redukcí. Některé z těchto látek mají protiretrovirový účinek (cs)
Title	Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds Syntéza a protivirová aktivita 2,4-diamino-5-kyano-6-[2-(fosfonomethoxy)ethoxy]pyrimidinu a příbuzných sloučenin (cs) Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds (en)
skos:prefLabel	Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds Syntéza a protivirová aktivita 2,4-diamino-5-kyano-6-[2-(fosfonomethoxy)ethoxy]pyrimidinu a příbuzných sloučenin (cs) Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds (en)
skos:notation	RIV/61388963:_____/04:00100860!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	3197;3202
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS4055109), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Hocková, Dana Holý, Antonín Masojídková, Milena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	589313
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100860
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nucleotide analogues;antiviral;pyrimidines (en)
http://linked.open.../riv/klicoveSlovo	antiviral nucleotide analogues pyrimidines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9E6323F8D3FC]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Acyclic nucleoside phosponates with antineoplastic activity
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Andrei, G. Balzarini, J. Holý, Antonín Hocková, Dana Snoeck, R. De Clercq, E. Masojídková, Milena
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0968-0896
number of pages	6 (xsd:int)

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