About: Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain

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About: Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byla studováva role tří vysoce konzervovaných aminokyselin insulinu PheB24, PheB25 a TyrB26 pro lepší porozumění strukturně-funkčního vztahu mezi insulinem a jeho receptorem. Deset zkrácených analogů insulinu s modifikacemi v beta-struktuře na B-řetězci bylo syntetizováno trypsinem katalyzovanou semisyntézou desoktapeptid(B23-B30)-insulinu s syntetickými peptidy. Insulinové analogy se záměnou jedné mainokyseliny v pozici B26 a možnou N-methylací peptidové vazby v různých pozicích byly zkráceny na C-konci B-řetězce o 4 aminokyseliny (cs) The role of three highly conserved insulin residues PheB24, PheB25, and TyrB26 was studied to better understand the subtleties of the structure - function relationship between insulin and its receptor. Ten shortened insulin analogues with modifications in the beta-strand of the B-chain were synthesized by trypsin-catalyzed coupling of des-octapeptide (B23-B30)-insulin with synthetic peptides. Insulin analogues with a single amino acid substitution in the position B26 and/or single N-methylation of the peptide bond at various positions were all shortened in the C-terminus of the B-chain by four amino acids The role of three highly conserved insulin residues PheB24, PheB25, and TyrB26 was studied to better understand the subtleties of the structure - function relationship between insulin and its receptor. Ten shortened insulin analogues with modifications in the beta-strand of the B-chain were synthesized by trypsin-catalyzed coupling of des-octapeptide (B23-B30)-insulin with synthetic peptides. Insulin analogues with a single amino acid substitution in the position B26 and/or single N-methylation of the peptide bond at various positions were all shortened in the C-terminus of the B-chain by four amino acids (en)
Title	Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain (en) Zkrácené analogy insulinu: Výrazné změny biologické aktivity vyplývající ze záměny TyrB26 a N-methylace peptidové vazby na C-konci B-řetězce insulinu (cs)
skos:prefLabel	Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain Shortened Insulin Analogues: Marked Changes in Biological Activity Resulting from Replacement of TyrB26 and N-Methylation of Peptide Bonds in the C-Terminus of the B-Chain (en) Zkrácené analogy insulinu: Výrazné změny biologické aktivity vyplývající ze záměny TyrB26 a N-methylace peptidové vazby na C-konci B-řetězce insulinu (cs)
skos:notation	RIV/61388963:_____/04:00100812!RIV/2005/AV0/A57005/N
http://linked.open.../vavai/riv/strany	2323;2331
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IBS4055006), P(PZ-Z2/32), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Jiráček, Jiří Žáková, Lenka Barth, Tomislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	586112
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100812
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	insulin analogues;biological activity;N-methylation (en)
http://linked.open.../riv/klicoveSlovo	N-methylation biological activity insulin analogues
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F4826350350B]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Human insulin and its analogues: Semisynthetic approache. Employment of biologically active compounds in the reproduction and aquaculture of fish
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Jiráček, Jiří Žáková, Lenka Barth, Tomislav Zórad, Š. Barthová, J.
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0006-2960
number of pages	9 (xsd:int)

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