About: The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon

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About: The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byla studována účinnost difosfátu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu (HPMPApp) jako substrátu DNA-polymeras. Míra inkorporace HPMPApp byla vyšší pro pol epsílon než pro pol delta ale 5,4 až 23 krát nižší než inkorporace dATP, což je nejspíše příčinou celulární toxicity a virostatické aktivity vůči polyomavirům (cs) In this study the substrate potency of (S)-9-[(3-hydroxy-2-phosphonomethoxy)-propyl]adenine diphosphate (HPMPApp) toward DNA polymerases was examined. It was found that efficiency of HPMPApp incorporation decreased in the order pol epsilon > pol delta and was from 5.4 to 23 fold lower than that of dATP. These observations might contribute to cellular toxicity of HPMPA and explain its antiviral activity against polyomavirus In this study the substrate potency of (S)-9-[(3-hydroxy-2-phosphonomethoxy)-propyl]adenine diphosphate (HPMPApp) toward DNA polymerases was examined. It was found that efficiency of HPMPApp incorporation decreased in the order pol epsilon > pol delta and was from 5.4 to 23 fold lower than that of dATP. These observations might contribute to cellular toxicity of HPMPA and explain its antiviral activity against polyomavirus (en)
Title	The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon Substrátová aktivita difosfátu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu k DNA-polymerasám alfa, delta a epsílon (cs) The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon (en)
skos:prefLabel	The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon Substrátová aktivita difosfátu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu k DNA-polymerasám alfa, delta a epsílon (cs) The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon (en)
skos:notation	RIV/61388963:_____/04:00100808!RIV/2005/GA0/A57005/N
http://linked.open.../vavai/riv/strany	23;33
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/01/1166), P(IBS4055109), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Votruba, Ivan Rosenberg, Ivan Holý, Antonín Rejman, Dominik Otmar, Miroslav Birkuš, Gabriel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	588942
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/04:00100808
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HPMPA; cellular DNA polymerases; HPMPC (en)
http://linked.open.../riv/klicoveSlovo	HPMPA cellular DNA polymerases HPMPC
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C45082C11A3D]
http://linked.open...i/riv/nazevZdroje	Antiviral Chemistry & Chemotherapy
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel oligonucleotides containing nonisosteric, enzyme-stable phosphonate linkages : systematic physico-chemical study on structure variants Acyclic nucleoside phosponates with antineoplastic activity
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Holý, Antonín Rosenberg, Ivan Votruba, Ivan Rejman, Dominik Otmar, Miroslav Birkuš, Gabriel
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0956-3202
number of pages	11 (xsd:int)

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