About: Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase.

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About: Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The results reported in this study validate the concept that combining combinatorial chemistry to affinity chromatography makes possible to identify, without any a priori hypothesis, novel protein targets for phosphinic pseudopeptides. And vice versa , selective inhibitors of BHMT were developed despite rather limited diversity of pseudopeptide library used to fish out the proteins. The results reported in this study validate the concept that combining combinatorial chemistry to affinity chromatography makes possible to identify, without any a priori hypothesis, novel protein targets for phosphinic pseudopeptides. And vice versa , selective inhibitors of BHMT were developed despite rather limited diversity of pseudopeptide library used to fish out the proteins. (en)
Title	Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase. Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase. (en)
skos:prefLabel	Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase. Combining combinatorial chemistry and affinity chromatography for systematically probing protein-ligand interactions: application to the development of highly selective inhibitors of human betaine: homocysteine S -methyltransferase. (en)
skos:notation	RIV/61388963:_____/02:57030167!RIV/2004/AV0/A57004/N
http://linked.open.../vavai/riv/strany	942;943
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAB4055003), Z(AV0Z4055905)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Jiráček, Jiří Collinsová, Michaela
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	641180
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/02:57030167
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BHMT; inhibitor; affinity chromatography (en)
http://linked.open.../riv/klicoveSlovo	affinity chromatography BHMT inhibitor
http://linked.open...ontrolniKodProRIV	[77E3E74B9590]
http://linked.open...v/mistoKonaniAkce	Sorrento [IT]
http://linked.open...i/riv/mistoVydani	Napoli
http://linked.open...i/riv/nazevZdroje	Peptides 2002. Proceedings of the Twenty-Seventh European Peptide Symposium.
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Application of combinatorial libraries of affinity carriers for the identificatio of new interactions of the protein-ligand type
http://linked.open...UplatneniVysledku	2002
http://linked.open...iv/tvurceVysledku	Jiráček, Jiří Garrow, T. A. Collinsová, Michaela Dive, V. Yiotakis, A. Castro, C.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2002-08-31 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Edizioni Ziino
https://schema.org/isbn	88-900948-1-8

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