About: Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes.

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About: Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Substrate activity and inhibitory potency of guanine and structurally related 2,6-diaminopurine phosphonomethoxyalkyl derivatives towards GMP kinase isoenzymes from L1210 cells was studied. Kinetic data have shown that (R)-PMPG was a good substrate. The inhibitory activities of the individual compounds on GMP kinase isoenzymes decreased in the following order: (S)-HPMPG>(R)-PMPG>PMEG>(R)-HPMPG>(S)-PMPG>PMEDAP=(R)-PMPDAP=(S)-PMPDAP. Substrate activity and inhibitory potency of guanine and structurally related 2,6-diaminopurine phosphonomethoxyalkyl derivatives towards GMP kinase isoenzymes from L1210 cells was studied. Kinetic data have shown that (R)-PMPG was a good substrate. The inhibitory activities of the individual compounds on GMP kinase isoenzymes decreased in the following order: (S)-HPMPG>(R)-PMPG>PMEG>(R)-HPMPG>(S)-PMPG>PMEDAP=(R)-PMPDAP=(S)-PMPDAP. (en)
Title	Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes. Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes. (en)
skos:prefLabel	Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes. Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes. (en)
skos:notation	RIV/61388963:_____/00:57000293!RIV/2003/AV0/A57003/N
http://linked.open.../vavai/riv/strany	1907;1913
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV203/96/K001), P(NL5423), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Horská, Květoslava Votruba, Ivan Krejčová, Romana Holý, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	713933
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/00:57000293
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1F4D09CB68C0]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology. 3
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of Antiviral and Anticancer Drugs with Acyclic Nucleotide Structure: Rational Design Based on Their Interference with Cellular Metabolism. 9-(2-Phosphonomethoxyethyl)-2, 6-dianomipurine (PMEDAP) and derivatives: potencial drugs against hematological malignancies
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Holý, Antonín Votruba, Ivan Horská, Květa Krejčová, Romana
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0006-2952
number of pages	7 (xsd:int)

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