About: Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells.

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About: Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Substrate activity of purine (phosphonomethoxy)alkyl derivatives towards mitochondrial AMP kinase (AK2 type) from L1210 cells was studied. The native AMP kinase, purified nearly to homogeneity, is a monomer with molecular weight 26 kDa. Substrate activity decreases in the order (S)-HPMPA>(R)-PMPA>PMEA>PMEDAP>(S)-PMPDAP>(R)-PMPDAP>>(S)-PMPA. Acyclic nucleotide analogues do not exhibit any inhibitory activity towards AK2 isoenzyme. Substrate activity of purine (phosphonomethoxy)alkyl derivatives towards mitochondrial AMP kinase (AK2 type) from L1210 cells was studied. The native AMP kinase, purified nearly to homogeneity, is a monomer with molecular weight 26 kDa. Substrate activity decreases in the order (S)-HPMPA>(R)-PMPA>PMEA>PMEDAP>(S)-PMPDAP>(R)-PMPDAP>>(S)-PMPA. Acyclic nucleotide analogues do not exhibit any inhibitory activity towards AK2 isoenzyme. (en)
Title	Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. (en)
skos:prefLabel	Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. (en)
skos:notation	RIV/61388963:_____/00:57000278!RIV/2003/AV0/A57003/N
http://linked.open.../vavai/riv/strany	1653;1668
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GV203/96/K001), P(NL5423), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Horská, Květoslava Votruba, Ivan Krejčová, Romana Holý, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	721533
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/00:57000278
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	N/A (en)
http://linked.open.../riv/klicoveSlovo	N/A
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[89999F238507]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of Antiviral and Anticancer Drugs with Acyclic Nucleotide Structure: Rational Design Based on Their Interference with Cellular Metabolism. 9-(2-Phosphonomethoxyethyl)-2, 6-dianomipurine (PMEDAP) and derivatives: potencial drugs against hematological malignancies
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	65
http://linked.open...iv/tvurceVysledku	Holý, Antonín Votruba, Ivan Horská, Květa Krejčová, Romana
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0010-0765
number of pages	16 (xsd:int)

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