About: Comprehensive portrait of cholesterol containing oxidized membrane

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Biologicalmembranes are under significant oxidative stress caused by reactive oxygen species mostly originating during cellular respiration. Double bonds of the unsaturated lipids are most prone to oxidation,which might lead to shortening of the oxidized chain and inserting of terminal either aldehyde or carboxylic group. Structural rearrangement of oxidized lipids, addressed already, is mainly associated with looping back of the hydrophilic terminal group. This contribution utilizing dual-focus fluorescence correlation spectroscopy and electron paramagnetic resonance as well as atomistic molecular dynamics simulations focuses on the overall changes of the membrane structural and dynamical properties once it becomes oxidized. Particularly, attention is paid to cholesterol rearrangement in the oxidized membrane revealing its preferable interaction with carbonyls of the oxidized chains. In this view cholesterol seems to have a tendency to repair, rather than condense, the bilayer. Biologicalmembranes are under significant oxidative stress caused by reactive oxygen species mostly originating during cellular respiration. Double bonds of the unsaturated lipids are most prone to oxidation,which might lead to shortening of the oxidized chain and inserting of terminal either aldehyde or carboxylic group. Structural rearrangement of oxidized lipids, addressed already, is mainly associated with looping back of the hydrophilic terminal group. This contribution utilizing dual-focus fluorescence correlation spectroscopy and electron paramagnetic resonance as well as atomistic molecular dynamics simulations focuses on the overall changes of the membrane structural and dynamical properties once it becomes oxidized. Particularly, attention is paid to cholesterol rearrangement in the oxidized membrane revealing its preferable interaction with carbonyls of the oxidized chains. In this view cholesterol seems to have a tendency to repair, rather than condense, the bilayer. (en)
Title	Comprehensive portrait of cholesterol containing oxidized membrane Comprehensive portrait of cholesterol containing oxidized membrane (en)
skos:prefLabel	Comprehensive portrait of cholesterol containing oxidized membrane Comprehensive portrait of cholesterol containing oxidized membrane (en)
skos:notation	RIV/61388955:_____/14:00427792!RIV15-GA0-61388955
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GBP208/12/G016), P(LH13259)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Štefl, Martin Šachl, Radek Hof, Martin Humpolíčková, Jana Cwiklik, Lukasz Olžyńska, Agnieszka Amaro, Mariana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	8434
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/14:00427792
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oxidized lipids; lateral diffusion; molecular dynamics simulations (en)
http://linked.open.../riv/klicoveSlovo	molecular dynamics simulations oxidized lipids lateral diffusion
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[313A78474AF8]
http://linked.open...i/riv/nazevZdroje	Biochimica Et Biophysica Acta-Biomembranes
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Controlling structure and function of biomolecules at the molecular scale: theory meets experiment Membrane interactions of proteins associated with alzheimer's disease and parkinson's disease implications for diseases' pathologies and therapeutic avenues
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	1838
http://linked.open...iv/tvurceVysledku	Cwiklik, Lukasz Hof, Martin Štefl, Martin Olžyńska, Agnieszka Šachl, Radek Humpolíčková, Jana Deyneka, Alexander Savchenko, Dariia Amaro, Mariana Hermetter, A.
http://linked.open...ain/vavai/riv/wos	000336695300009
issn	0005-2736
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbamem.2014.02.006

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