About: Behavior of 4-Hydroxynonenal in Phospholipid Membranes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Under conditions of oxidative stress, 4-hydroxy-2-nonenal (4-HNE) is commonly present in vivo. This highly reactive and cytotoxic compound is generated by oxidation of lipids in membranes and can be easily transferred from a membrane to both cytosol and the extracellular space. Employing time-dependent fluorescence shift (TDFS) method and molecular dynamics simulations, we found that 4-HNE is stabilized in the carbonyl region of a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayer. 4-HNE is thus able to react with cell membrane proteins and lipids. Stabilization in the membrane is, however, moderate and a transfer of 4-HNE to either extra- or intracellular space occurs on a microsecond time scale. These molecular-level details of 4-HNE behavior in the lipid membrane rationalize the experimentally observed reactivity of 4-HNE with proteins inside and outside the cell. Furthermore, these results support the view that 4-HNE may play an active role in cell signaling pathways. Under conditions of oxidative stress, 4-hydroxy-2-nonenal (4-HNE) is commonly present in vivo. This highly reactive and cytotoxic compound is generated by oxidation of lipids in membranes and can be easily transferred from a membrane to both cytosol and the extracellular space. Employing time-dependent fluorescence shift (TDFS) method and molecular dynamics simulations, we found that 4-HNE is stabilized in the carbonyl region of a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayer. 4-HNE is thus able to react with cell membrane proteins and lipids. Stabilization in the membrane is, however, moderate and a transfer of 4-HNE to either extra- or intracellular space occurs on a microsecond time scale. These molecular-level details of 4-HNE behavior in the lipid membrane rationalize the experimentally observed reactivity of 4-HNE with proteins inside and outside the cell. Furthermore, these results support the view that 4-HNE may play an active role in cell signaling pathways. (en)
Title	Behavior of 4-Hydroxynonenal in Phospholipid Membranes Behavior of 4-Hydroxynonenal in Phospholipid Membranes (en)
skos:prefLabel	Behavior of 4-Hydroxynonenal in Phospholipid Membranes Behavior of 4-Hydroxynonenal in Phospholipid Membranes (en)
skos:notation	RIV/61388955:_____/12:00378708!RIV13-GA0-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/08/0114), P(GAP208/10/0376), P(GEMEM/09/E006), P(LH12001), Z(AV0Z40400503), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hof, Martin Jurkiewicz, Piotr Cwiklik, Lukasz
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	124635
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/12:00378708
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fluorescence spectroscopy; molecular dynamics; membranes; 4-hydroxynonenal (en)
http://linked.open.../riv/klicoveSlovo	fluorescence spectroscopy membranes 4-hydroxynonenal molecular dynamics
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1C02F2571DC8]
http://linked.open...i/riv/nazevZdroje	Journal of Physical Chemistry B
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of antibacterial peptides with the model membranes and possibility of the prediction of their biological activity Modelling of potassium transport in the inner ear Specific ion effects for proteins in solutions and related biologically relevant systems. Molecular level physiology and pathology of oxidized phospholipids
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	116
http://linked.open...iv/tvurceVysledku	Cwiklik, Lukasz Hof, Martin Jurkiewicz, Piotr Jungwirth, Pavel Vazdar, Mario
http://linked.open...ain/vavai/riv/wos	000304888600019
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1520-6106
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jp3044219

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