About: METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Radiosensitizers belong to the most important class of the cancerostatic drugs. The electrochemical transfer of the first electron to the cytotoxic radiosensitizer Metronidazole (MET) and MET radical anion formation in aprotic medium was studied by means of electrochemical impedance spectroscopy. The heterogeneous electron transfer rate constant for the first reduction of MET (radical anion production) k0 for the redox couple was determined. Similarly, the diffusion coefficient of MET in dimethylformamide was also calculated by impedance measurements using expression for Warburg coefficient and Warburg plot. Moreover, the equivalent circuit for the redox couple MET/MET– was proposed and its parameters were evaluated using a non-linear least square fitting. Our results, from the electrochemical point of view, also confirm the suitability of MET for the effective treatment of selected types of the cancer. Radiosensitizers belong to the most important class of the cancerostatic drugs. The electrochemical transfer of the first electron to the cytotoxic radiosensitizer Metronidazole (MET) and MET radical anion formation in aprotic medium was studied by means of electrochemical impedance spectroscopy. The heterogeneous electron transfer rate constant for the first reduction of MET (radical anion production) k0 for the redox couple was determined. Similarly, the diffusion coefficient of MET in dimethylformamide was also calculated by impedance measurements using expression for Warburg coefficient and Warburg plot. Moreover, the equivalent circuit for the redox couple MET/MET– was proposed and its parameters were evaluated using a non-linear least square fitting. Our results, from the electrochemical point of view, also confirm the suitability of MET for the effective treatment of selected types of the cancer. (en)
Title	METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (en)
skos:prefLabel	METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (en)
skos:notation	RIV/61388955:_____/11:00371757!RIV12-GA0-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/09/P502), P(LC510), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sokolová, Romana Gál, Miroslav Kolivoška, Viliam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	212144
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/11:00371757
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	radicals; radiopharmaceuticals; electron transfer (en)
http://linked.open.../riv/klicoveSlovo	electron transfer radicals radiopharmaceuticals
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[4799A0409AAE]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of nanotechnology and materials for nanoelectronics Electrochemical Study of Redox Reactions of Radiosensitizers: Drugs that Make Radiation Work Better in Destroying Cancer Cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Ambrová, M. Gál, Miroslav Híveš, J. Kolivoška, Viliam Sokolová, Romana Morovská Turoňová, A.
http://linked.open...ain/vavai/riv/wos	000299816100013
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	0010-0765
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1135/cccc2011113

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