About: Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations

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About: Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Radiosensitizers are drugs that make cancer cells more sensitive to radiation therapy. The cytotoxic properties of such compounds are due to the fact that in the cell these compounds undergo one-electron reduction to generate radical anions. Therefore, their theoretical and/or experimental study is of high interest. To determine the correlation between reduction potential determined by cyclic voltammetry measurements and some physicochemical properties of selected radiosensitizers theoretical calculations of electron affinities based on the DFT method with B3LYP functional at the level of 6-311++G basis set in vacuum were utilized. Very good correlation was found between electron affinities of radiosensitizers and their reduction potential and so called E71 potential that account for the energy necessary to transfer the first electron to an electroactive group at pH 7 in aqueous medium to form a radical anion. Radiosensitizers are drugs that make cancer cells more sensitive to radiation therapy. The cytotoxic properties of such compounds are due to the fact that in the cell these compounds undergo one-electron reduction to generate radical anions. Therefore, their theoretical and/or experimental study is of high interest. To determine the correlation between reduction potential determined by cyclic voltammetry measurements and some physicochemical properties of selected radiosensitizers theoretical calculations of electron affinities based on the DFT method with B3LYP functional at the level of 6-311++G basis set in vacuum were utilized. Very good correlation was found between electron affinities of radiosensitizers and their reduction potential and so called E71 potential that account for the energy necessary to transfer the first electron to an electroactive group at pH 7 in aqueous medium to form a radical anion. (en)
Title	Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations (en)
skos:prefLabel	Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations Correlation of the first reduction potential of selected radiosensitizers determined by cyclic voltammetry with theoretical calculations (en)
skos:notation	RIV/61388955:_____/11:00361508!RIV12-GA0-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/0705), P(GP203/09/P502), P(LC510), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Sokolová, Romana Gál, Miroslav Kolivoška, Viliam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	192059
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/11:00361508
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cyclic voltammetry; radical ions; radiochemistry (en)
http://linked.open.../riv/klicoveSlovo	cyclic voltammetry radical ions radiochemistry
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[02DF91131C22]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of nanotechnology and materials for nanoelectronics Transfer of charge in single and assembled molecules Electrochemical Study of Redox Reactions of Radiosensitizers: Drugs that Make Radiation Work Better in Destroying Cancer Cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Ambrová, M. Gál, Miroslav Híveš, J. Kolivoška, Viliam Sokolová, Romana
http://linked.open...ain/vavai/riv/wos	000298002900001
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	0010-0765
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1135/cccc2011067

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