About: Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Electrochemical transfer of the first electron to cytotoxic radiosensitizer etanidazole (ETN) and ETN radical anion formation in the alkaline buffered aqueous solution were studied by means of electrochemical impedance spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production), k(0), was calculated. The value of k(0) from EIS measurements and the previously obtained value of so-called E-7(1) potential indicate that ETN, compared with other possible chemical radiosensitizers, requires lower energy to accept the first electron during the metabolic pathway. However, the necessity of the alkaline pH may decrease the ability of ETN to act as hypoxic radiosensitizer in the human body. Electrochemical transfer of the first electron to cytotoxic radiosensitizer etanidazole (ETN) and ETN radical anion formation in the alkaline buffered aqueous solution were studied by means of electrochemical impedance spectroscopy (EIS). The heterogeneous electron transfer rate constant for the first reduction of ETN (radical anion production), k(0), was calculated. The value of k(0) from EIS measurements and the previously obtained value of so-called E-7(1) potential indicate that ETN, compared with other possible chemical radiosensitizers, requires lower energy to accept the first electron during the metabolic pathway. However, the necessity of the alkaline pH may decrease the ability of ETN to act as hypoxic radiosensitizer in the human body. (en)
Title	Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water (en)
skos:prefLabel	Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water Impendance Study of Hypoxic Cells Radiosensitizer Etanidazole Radical Anion in Water (en)
skos:notation	RIV/61388955:_____/09:00340611!RIV10-MSM-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/0705), P(GP203/09/P502), P(LC510), P(OC 140), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	11-12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pospíšil, Lubomír Sokolová, Romana Hromadová, Magdaléna Gál, Miroslav Kolivoška, Viliam
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	318674
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/09:00340611
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	electrochemistry; electrochemical characteristics; aromatic nitro-compounds (en)
http://linked.open.../riv/klicoveSlovo	electrochemistry aromatic nitro-compounds electrochemical characteristics
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[A547D79BE79F]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of nanotechnology and materials for nanoelectronics Transfer of charge in single and assembled molecules Electrochemical Study of Redox Reactions of Radiosensitizers: Drugs that Make Radiation Work Better in Destroying Cancer Cells http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20140
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Gál, Miroslav Hromadová, Magdaléna Híveš, J. Kolivoška, Viliam Pospíšil, Lubomír Sokolová, Romana
http://linked.open...ain/vavai/riv/wos	000274667900001
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	0010-0765
number of pages	11 (xsd:int)

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