About: Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new simple and direct electroanalytical method was developed for the determination of azidothymidine in commercial pharmaceutical preparations. It is based on differential pulse voltammetry at silver solid amalgam electrode with polished surface (p-AgSAE) or surface modified by mercury meniscus (m-AgSAE). The electroreduction of azidothymidine in basic media at these electrodes gives rise to one irreversible cathodic peak. Its potential in 0.05 mol L-1 borate buffer, pH 9.3 at ca. -1050 mV is comparable to that using hanging mercury drop electrode (HMDE). Achieved limits of quantitation are in the 10-7 mol L-1 concentration range for both amalgam electrodes. According to the procedure based on the standard addition technique, the recoveries of known amounts of azidothymidine contained in pharmaceutical preparations available in capsules were 101.41.8% (m-AgSAE), 100.33.5% (p-AgSAE) and 102.01.0% (HMDE) (n=10). A new simple and direct electroanalytical method was developed for the determination of azidothymidine in commercial pharmaceutical preparations. It is based on differential pulse voltammetry at silver solid amalgam electrode with polished surface (p-AgSAE) or surface modified by mercury meniscus (m-AgSAE). The electroreduction of azidothymidine in basic media at these electrodes gives rise to one irreversible cathodic peak. Its potential in 0.05 mol L-1 borate buffer, pH 9.3 at ca. -1050 mV is comparable to that using hanging mercury drop electrode (HMDE). Achieved limits of quantitation are in the 10-7 mol L-1 concentration range for both amalgam electrodes. According to the procedure based on the standard addition technique, the recoveries of known amounts of azidothymidine contained in pharmaceutical preparations available in capsules were 101.41.8% (m-AgSAE), 100.33.5% (p-AgSAE) and 102.01.0% (HMDE) (n=10). (en)
Title	Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes (en)
skos:prefLabel	Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes Voltammetric Determination of Azidothymidine Using Silver Solid Amalgam Electrodes (en)
skos:notation	RIV/61388955:_____/09:00328330!RIV10-MSM-61388955
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/1195), P(IAA400400806), P(LC06035), Z(AV0Z40400503), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Navrátil, Tomáš Yosypchuk, Bogdan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	349859
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/09:00328330
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	azidothymidine; Zidovudine; Silver solid amalgam electrode; Differential pulse voltammetry (en)
http://linked.open.../riv/klicoveSlovo	Zidovudine Differential pulse voltammetry Silver solid amalgam electrode azidothymidine
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[A6234D73F057]
http://linked.open...i/riv/nazevZdroje	Electroanalysis
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Transport of Charged and Uncharged Species across Models of Biological Membranes Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Analysis of DNA structure and interactions using electrochemical techniques and chemical probes. Novel techniques and sensors for DNA damage detection
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Barek, J. Navrátil, Tomáš Yosypchuk, Bogdan Pecková, K. Moreira, J. C. Leandro, K. Ch.
http://linked.open...ain/vavai/riv/wos	000268790300013
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1040-0397
number of pages	8 (xsd:int)

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