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rdf:type
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Description
| - Transient radicals that correspond to adducts with a hydrogen atom positioned at N3 and C5 of the cytosine ring have been specifically generated in the gas phase for the first time. These isomeric radicals are found to be intrinsically stable, distinct species that show specific unimolecular dissociations by loss of a hydrogen atom or the CH3 group and ring cleavage followed by expulsion of small molecules. It can be expected that substituents at N1 larger than a methyl group (for example, 2’-deoxyribos-1-yl) would increase the propensity for N1-C bond dissociation in cytidine radicals, as the proposed mechanisms for nucleobase loss from radiation damage to DNA suggest.
- Transient radicals that correspond to adducts with a hydrogen atom positioned at N3 and C5 of the cytosine ring have been specifically generated in the gas phase for the first time. These isomeric radicals are found to be intrinsically stable, distinct species that show specific unimolecular dissociations by loss of a hydrogen atom or the CH3 group and ring cleavage followed by expulsion of small molecules. It can be expected that substituents at N1 larger than a methyl group (for example, 2’-deoxyribos-1-yl) would increase the propensity for N1-C bond dissociation in cytidine radicals, as the proposed mechanisms for nucleobase loss from radiation damage to DNA suggest. (en)
- Specificky byly připraveny radikály odpovídající aduktům vodíkového atomu do polohy N3 a C5 1-methylcytosinu. Bylo zjištěno, že tyto radikály jsou stabilní spécie, které vykazují specifické monomolekulární disociace odstěpením atomu vodíku nebo skupiny CH3, a štěpení kruhu následované eliminací malých molekul. Lze očekávat, že N1 substituenty větší než methylová skupina (např. 2'-deoxyribos-1-yl) zvýší schopnost disociace vazby N1-C v cytidinových radikálech, tak jak předpokládají navrhované mechanizmy ztrát nukleobází při radiativním poškozování DNA. (cs)
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Title
| - Specific generation of 1-methylcytosine radicals in the gas phase
- Specifická příprava radikalů 1-methylcytosinu v plynné fázi (cs)
- Specific generation of 1-methylcytosine radicals in the gas phase (en)
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skos:prefLabel
| - Specific generation of 1-methylcytosine radicals in the gas phase
- Specifická příprava radikalů 1-methylcytosinu v plynné fázi (cs)
- Specific generation of 1-methylcytosine radicals in the gas phase (en)
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skos:notation
| - RIV/61388955:_____/05:00023556!RIV06-AV0-61388955
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(IAA400400502), Z(AV0Z40400503)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388955:_____/05:00023556
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - potential-energy surfaces; cytosine; mass spectrometry; radicals (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Angewandte Chemie. International Edition in English
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Polášek, Miroslav
- Tureček, F.
- Cuadrado-Peinado, M. L.
- Yao, Ch.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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