About: Specific generation of 1-methylcytosine radicals in the gas phase

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Description	Transient radicals that correspond to adducts with a hydrogen atom positioned at N3 and C5 of the cytosine ring have been specifically generated in the gas phase for the first time. These isomeric radicals are found to be intrinsically stable, distinct species that show specific unimolecular dissociations by loss of a hydrogen atom or the CH3 group and ring cleavage followed by expulsion of small molecules. It can be expected that substituents at N1 larger than a methyl group (for example, 2’-deoxyribos-1-yl) would increase the propensity for N1-C bond dissociation in cytidine radicals, as the proposed mechanisms for nucleobase loss from radiation damage to DNA suggest. Transient radicals that correspond to adducts with a hydrogen atom positioned at N3 and C5 of the cytosine ring have been specifically generated in the gas phase for the first time. These isomeric radicals are found to be intrinsically stable, distinct species that show specific unimolecular dissociations by loss of a hydrogen atom or the CH3 group and ring cleavage followed by expulsion of small molecules. It can be expected that substituents at N1 larger than a methyl group (for example, 2’-deoxyribos-1-yl) would increase the propensity for N1-C bond dissociation in cytidine radicals, as the proposed mechanisms for nucleobase loss from radiation damage to DNA suggest. (en) Specificky byly připraveny radikály odpovídající aduktům vodíkového atomu do polohy N3 a C5 1-methylcytosinu. Bylo zjištěno, že tyto radikály jsou stabilní spécie, které vykazují specifické monomolekulární disociace odstěpením atomu vodíku nebo skupiny CH3, a štěpení kruhu následované eliminací malých molekul. Lze očekávat, že N1 substituenty větší než methylová skupina (např. 2'-deoxyribos-1-yl) zvýší schopnost disociace vazby N1-C v cytidinových radikálech, tak jak předpokládají navrhované mechanizmy ztrát nukleobází při radiativním poškozování DNA. (cs)
Title	Specific generation of 1-methylcytosine radicals in the gas phase Specifická příprava radikalů 1-methylcytosinu v plynné fázi (cs) Specific generation of 1-methylcytosine radicals in the gas phase (en)
skos:prefLabel	Specific generation of 1-methylcytosine radicals in the gas phase Specifická příprava radikalů 1-methylcytosinu v plynné fázi (cs) Specific generation of 1-methylcytosine radicals in the gas phase (en)
skos:notation	RIV/61388955:_____/05:00023556!RIV06-AV0-61388955
http://linked.open.../vavai/riv/strany	6708;6711
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA400400502), Z(AV0Z40400503)
http://linked.open...iv/cisloPeriodika	41
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Polášek, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	543839
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/05:00023556
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	potential-energy surfaces; cytosine; mass spectrometry; radicals (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry cytosine potential-energy surfaces radicals
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[EF96C5410555]
http://linked.open...i/riv/nazevZdroje	Angewandte Chemie. International Edition in English
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Unimolecular reaction kinetics of the gas phase radicals
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Polášek, Miroslav Tureček, F. Cuadrado-Peinado, M. L. Yao, Ch.
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace
issn	1433-7851
number of pages	4 (xsd:int)

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