About: Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding.

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About: Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding. Goto Sponge NotDistinct Permalink

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Description	Chloroform- and Freon-soluble mixed thymine, adenine complexes trans-[Pt(MeNH2)(2)(ChmT-N-3)(ChmA-N1)]NO3 (2) and trans-[Pt(MeNH2)(2)(ChmT-N3)(TBDMS-ado-N1)]BF4 (3) (ChmT = anion of 1-cyclohexylmethylthymine ChmTH, ChmA = 9-cyclohexylmethyladenine, TBDMS-ado = 2 ,3'', 5''-tri-tert-butyldimethylsilyladenosine) have been prepared and characterized to study their propensity to undergo Hoogsteen and/or reversed Hoogsteen pairing in solution with free ChmTH and free 3'',5''-diacetyl-2'' -deoxyuridine, respectively, No Hoogsteen or reversed Hoogsteen pairing between 2 and ChmT takes place in CDCl3. In Freon, partial H bonding between N1 platinated TBIDIVIS-ado and 3'',5 '' -diacetyl-2'' -deoxyuridine as well as its [3-N-15] labeled analogue is unambiguously observed only below 150 K. Comparison of (1)J (N-15-H-1) coupling constants of 3'',5''-diacetyl-2''''-deoxyuridine involved in Hoogsteen pairing with free and N1 platinated adenine suggests that the interaction. Chloroform- and Freon-soluble mixed thymine, adenine complexes trans-[Pt(MeNH2)(2)(ChmT-N-3)(ChmA-N1)]NO3 (2) and trans-[Pt(MeNH2)(2)(ChmT-N3)(TBDMS-ado-N1)]BF4 (3) (ChmT = anion of 1-cyclohexylmethylthymine ChmTH, ChmA = 9-cyclohexylmethyladenine, TBDMS-ado = 2 ,3'', 5''-tri-tert-butyldimethylsilyladenosine) have been prepared and characterized to study their propensity to undergo Hoogsteen and/or reversed Hoogsteen pairing in solution with free ChmTH and free 3'',5''-diacetyl-2'' -deoxyuridine, respectively, No Hoogsteen or reversed Hoogsteen pairing between 2 and ChmT takes place in CDCl3. In Freon, partial H bonding between N1 platinated TBIDIVIS-ado and 3'',5 '' -diacetyl-2'' -deoxyuridine as well as its [3-N-15] labeled analogue is unambiguously observed only below 150 K. Comparison of (1)J (N-15-H-1) coupling constants of 3'',5''-diacetyl-2''''-deoxyuridine involved in Hoogsteen pairing with free and N1 platinated adenine suggests that the interaction. (en)
Title	Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding. Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding. (en)
skos:prefLabel	Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding. Loss of Hoogsteen Pairing Ability upon N1 Adenine Platinum Binding. (en)
skos:notation	RIV/61388955:_____/02:54020098!RIV/2003/AV0/A54003/N
http://linked.open.../vavai/riv/strany	2855;2863
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA4040903), P(LN00A016), Z(AV0Z4040901)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Šponer, Jiří Šponer, Judit E.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav fyzikální chemie J. Heyrovského AV ČR, v.v.i.
http://linked.open...dnocenehoVysledku	652099
http://linked.open...ai/riv/idVysledku	RIV/61388955:_____/02:54020098
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenine; - thymine; - Hoogsteen pairing ability (en)
http://linked.open.../riv/klicoveSlovo	adenine - Hoogsteen pairing ability - thymine
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0E2605276A14]
http://linked.open...i/riv/nazevZdroje	Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	BIOMOLECULAR CENTER Interactions of metal cations with nucleic acids and their constituents. Ab initio quantum-chemical study
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Šponer, Jiří Šponer, Judit Erika Reedijk, J. Lippert, B. Janke, E. M. B. Schmidt, K. S. Weisz, K.
http://linked.open...n/vavai/riv/zamer	Objasňování zákonitostí vztahů struktury a vlastností - zejména dynamiky a chemické reaktivity - látek a molekulárních systémů
issn	0020-1669
number of pages	9 (xsd:int)

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