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  • In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer.
  • In the first case-control study on pancreatic cancer conducted on 253 cases and 403 controls in the Czech Republic we observed that the GSTP1-codon 105 Val variant allele and the GSTT1-null genotype were associated with an elevated risk for pancreatic cancer (OR = 1.38; 95%CI = 0.96-1.97 and OR = 1.56; 95%CI = 0.93-2.61, respectively). Combination of GSTT1-null and GSTP1-codon 105 Val variants further increased the risk for pancreatic cancer (OR = 2.50; 95%CI = 1.20-5.20). In conclusion, this study suggests population-specific associations of polymorphisms in key biotransformation genes with elevated risk for pancreatic cancer. (en)
Title
  • The association between Glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population
  • The association between Glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population (en)
skos:prefLabel
  • The association between Glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population
  • The association between Glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population (en)
skos:notation
  • RIV/61383082:_____/09:#0000050!RIV10-MO0-61383082
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 680
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http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
  • 304240
http://linked.open...ai/riv/idVysledku
  • RIV/61383082:_____/09:#0000050
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Genetic Predisposition to Disease; Polymorphism; Single Nucleotide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [B1A7696A70D2]
http://linked.open...i/riv/nazevZdroje
  • Mutation Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2009
http://linked.open...iv/tvurceVysledku
  • Ryska, Miroslav
  • Vrána, David
  • Strnad, Robin
issn
  • 0027-5107
number of pages
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