About: Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein

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About: Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV changes its morpho The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV changes its morpho (en)
Title	Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein (en)
skos:prefLabel	Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein (en)
skos:notation	RIV/60461373:22640/03:00008458!RIV/2004/GA0/226404/N
http://linked.open.../vavai/riv/strany	281
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/03/0490), P(LN00A079), Z(MSM 223300006)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Lipov, Jan Hrabal, Richard Rumlová, Michaela Ruml, Tomáš Veverka, Václav
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Centrální laboratoře
http://linked.open...dnocenehoVysledku	629279
http://linked.open...ai/riv/idVysledku	RIV/60461373:22640/03:00008458
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matrix protein, MPMV, Dtyp retrovirů, mutant R55W, NMR experiments, histidine tag (en)
http://linked.open.../riv/klicoveSlovo	matrix protein MPMV histidine tag Dtyp retrovirů NMR experiments mutant R55W
http://linked.open...ontrolniKodProRIV	[F7949CF2F661]
http://linked.open...v/mistoKonaniAkce	Drážďany
http://linked.open...i/riv/mistoVydani	Frankfurt/Main
http://linked.open...i/riv/nazevZdroje	ELSO Proceedings
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Integrated Genomics Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Hrabal, Richard Lipov, Jan Ruml, Tomáš Rumlová, Michaela Veverka, Václav
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2003-09-20 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20223300006
issn	0021-9524
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	GBM
http://localhost/t...ganizacniJednotka	22640

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