About: Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides.

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About: Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	9-(2-Deoxy-beta -D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-beta -D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity. 9-(2-Deoxy-beta -D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-beta -D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity. (en)
Title	Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides. Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides. (en)
skos:prefLabel	Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides. Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides. (en)
skos:notation	RIV/60461373:22640/01:00004557!RIV/2004/GA0/226404/N
http://linked.open.../vavai/riv/strany	483-499
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/00/0036), P(GV203/96/K001), Z(AV0Z4055905)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Dvořáková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Centrální laboratoře
http://linked.open...dnocenehoVysledku	676757
http://linked.open...ai/riv/idVysledku	RIV/60461373:22640/01:00004557
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purines, nucleosides, cross-coupling reactions, boronic acids, acyclic nucleoside analogues, 5 '-deoxyribunucleosides, 2 '-deoxyribonuclcosides, cytostatic activity, antitumor agents (en)
http://linked.open.../riv/klicoveSlovo	acyclic nucleoside analogues nucleosides boronic acids cytostatic activity cross-coupling reactions purines antitumor agents 2 '-deoxyribonuclcosides 5 '-deoxyribunucleosides
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2379ACE22386]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis of purine-purine and purine-pyrimidine dimers and purine trimers as analogues of Watson-Crick base pairs and Hoogsteen triplets Development of Antiviral and Anticancer Drugs with Acyclic Nucleotide Structure: Rational Design Based on Their Interference with Cellular Metabolism.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	66
http://linked.open...iv/tvurceVysledku	Hocek, Michal Holý, Antonín Votruba, Ivan Dvořáková, Hana
http://linked.open...n/vavai/riv/zamer	Chemical principles of selected biological phenomena in medicine and ecology
issn	0010-0765
number of pages	16 (xsd:int)
http://localhost/t...ganizacniJednotka	22640

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