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| rdf:type
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| Description
| - The objective of this study was to investigate the effect of different type of formulation (solid dispersion and physical mixture) with a poorly soluble active pharmaceutical ingredient (API) on water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, Scanning Electron Microscopy, moisture sorption analysis, infrared (IR) spectroscopy and ATR-FTIR Imaging during dissolution were performed on API-polymer system (Aprepitant-PVP). The amorphous solid dispersion was prepared by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherm was lower in comparison with the isotherms of physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. The dissolution of tablet was observed and the distribution of each component was determinated by the integral absorbance of corresponding bands. The dissolution rate of Aprepitant was significantly faster in formulation of solid dispersion. In both formulations the crystallization of Aprepitant was determinated during dissolution.
- The objective of this study was to investigate the effect of different type of formulation (solid dispersion and physical mixture) with a poorly soluble active pharmaceutical ingredient (API) on water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate of the API. X-ray diffraction, Scanning Electron Microscopy, moisture sorption analysis, infrared (IR) spectroscopy and ATR-FTIR Imaging during dissolution were performed on API-polymer system (Aprepitant-PVP). The amorphous solid dispersion was prepared by spray drying. The interactions between the API and polymer molecules caused the water sorption isotherms of solid dispersions to deviate from those of ideal mixtures. The moisture sorption isotherm was lower in comparison with the isotherms of physical mixtures. The nature of the API-polymer interaction was explained by shifts in the characteristic bands of the IR spectra of the solid dispersions compared to the pure components. The dissolution of tablet was observed and the distribution of each component was determinated by the integral absorbance of corresponding bands. The dissolution rate of Aprepitant was significantly faster in formulation of solid dispersion. In both formulations the crystallization of Aprepitant was determinated during dissolution. (en)
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| Title
| - Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate
- Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate (en)
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| skos:prefLabel
| - Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate
- Drug - polymer properties in solid dispersion and physical mixture and their effect to dissolution rate (en)
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| skos:notation
| - RIV/60461373:22340/14:43897697!RIV15-MSM-22340___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/14:43897697
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - dissolution rate; physical mixture; solid dispersion; polymer; Drug (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Štěpánek, František
- Punčochová, Kateřina
- Beránek, Josef
- Heng, Jerry Y. Y.
- Kazari, Sergei G .
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - Slovak Society of Chemical Engineering
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| https://schema.org/isbn
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| http://localhost/t...ganizacniJednotka
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