About: Preparation of liposomes-containing microparticles for drug targeting

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Previous studies in our laboratory showed methodology of preparing alginate particles immobilizing thermosensitive liposomes containing a model substance [1]. Those particles are able to store substances inside until heated. These particles are stable in diluted buffers, but they dissolve in isotonic solutions in a few hours. Before modifying their surface by antibodies and their in vitro specific adhesion and release tests, the mechanical and chemical stability in isotonic buffers must be improved. Calcium alginate gel particles will be therefore modified, the most perspective method seems to be utilization of chitosan as a co-crosslinker (together with Ca2+) and/or precipitation of thin silica layer on their surface. Previous studies in our laboratory showed methodology of preparing alginate particles immobilizing thermosensitive liposomes containing a model substance [1]. Those particles are able to store substances inside until heated. These particles are stable in diluted buffers, but they dissolve in isotonic solutions in a few hours. Before modifying their surface by antibodies and their in vitro specific adhesion and release tests, the mechanical and chemical stability in isotonic buffers must be improved. Calcium alginate gel particles will be therefore modified, the most perspective method seems to be utilization of chitosan as a co-crosslinker (together with Ca2+) and/or precipitation of thin silica layer on their surface. (en)
Title	Preparation of liposomes-containing microparticles for drug targeting Preparation of liposomes-containing microparticles for drug targeting (en)
skos:prefLabel	Preparation of liposomes-containing microparticles for drug targeting Preparation of liposomes-containing microparticles for drug targeting (en)
skos:notation	RIV/60461373:22340/14:43897683!RIV15-GA0-22340___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA13-09914S), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Gorný, Damian Štěpánek, František Tokárová, Viola Ullrich, Martin
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	39036
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/14:43897683
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug targeting; microparticles; liposomes (en)
http://linked.open.../riv/klicoveSlovo	microparticles drug targeting liposomes
http://linked.open...ontrolniKodProRIV	[8E7C69D80739]
http://linked.open...v/mistoKonaniAkce	Tatranské Matliare
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	A controlling of diffusion processes in pores with varying permeability
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Tokárová, Viola Štěpánek, František Ullrich, Martin Gorný, Damian
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2014-05-26 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Slovak Society of Chemical Engineering
https://schema.org/isbn	978-80-89475-13-1
http://localhost/t...ganizacniJednotka	22340

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