About: Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/ejoc.201301517
Description	An efficient approach for the synthesis of unsymmetrically substituted Troger's base derivatives is reported. This approach is based on the N-alkylation of an arylamine by tert-butyl [2-(bromomethyl)aryl]carbamate to give the corresponding diamine, which is subsequently converted into a Troger's base derivative using paraformaldehyde in trifluoroacetic acid. The mild conditions of this approach allow the preparation of Troger's base derivatives bearing electron-withdrawing functional groups sensitive to reducing conditions, as demonstrated by the preparation of twelve Troger's base derivatives in overall yields of 62 to 76%. An efficient approach for the synthesis of unsymmetrically substituted Troger's base derivatives is reported. This approach is based on the N-alkylation of an arylamine by tert-butyl [2-(bromomethyl)aryl]carbamate to give the corresponding diamine, which is subsequently converted into a Troger's base derivative using paraformaldehyde in trifluoroacetic acid. The mild conditions of this approach allow the preparation of Troger's base derivatives bearing electron-withdrawing functional groups sensitive to reducing conditions, as demonstrated by the preparation of twelve Troger's base derivatives in overall yields of 62 to 76%. (en)
Title	Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction (en)
skos:prefLabel	Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction Synthesis of Unsymmetrical Troger's Bases Bearing Groups Sensitive to Reduction (en)
skos:notation	RIV/60461373:22340/14:43897587!RIV15-GA0-22340___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP303/11/1291)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Král, Vladimír Jakubek, Milan Dolenský, Bohumil Havlík, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	49055
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/14:43897587
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Amines; Cyclization; Fused-ring systems; Nitrogen heterocycles; Synthetic methods (en)
http://linked.open.../riv/klicoveSlovo	Amines Fused-ring systems Nitrogen heterocycles Cyclization Synthetic methods
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[74376E2264C2]
http://linked.open...i/riv/nazevZdroje	European Journal of Organic Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	New types of ligands interfering with cancer cell communication as a new therapeutic strategy
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2014
http://linked.open...iv/tvurceVysledku	Jakubek, Milan Král, Vladimír Havlík, Martin Dolenský, Bohumil
http://linked.open...ain/vavai/riv/wos	000334783300020
issn	1434-193X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ejoc.201301517
http://localhost/t...ganizacniJednotka	22340

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