About: On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

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About: On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://scitation.aip.org/content/aip/journal/jcp/138/6/10.1063/1.4790126
Description	Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay between the single and double phosphorylation subnetworks in generating bistability. Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay between the single and double phosphorylation subnetworks in generating bistability. (en)
Title	On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling (en)
skos:prefLabel	On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling (en)
skos:notation	RIV/60461373:22340/13:43895784!RIV14-MSM-22340___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME10036)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hadač, Otto Přibyl, Michal Schreiber, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	93920
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/13:43895784
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CASCADES; TRANSDUCTION; SYSTEMS; STABILITY; PHOSPHORYLATION; STEADY-STATES; DEFICIENCY-ONE; KINASE PATHWAYS; REACTION NETWORK STRUCTURE; COMPLEX ISOTHERMAL REACTORS (en)
http://linked.open.../riv/klicoveSlovo	SYSTEMS STABILITY PHOSPHORYLATION CASCADES COMPLEX ISOTHERMAL REACTORS DEFICIENCY-ONE KINASE PATHWAYS REACTION NETWORK STRUCTURE STEADY-STATES TRANSDUCTION
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CF42B9B10483]
http://linked.open...i/riv/nazevZdroje	Journal of Chemical Physics
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	138
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Přibyl, Michal Hadač, Otto
http://linked.open...ain/vavai/riv/wos	000315054400043
issn	0021-9606
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1063/1.4790126
http://localhost/t...ganizacniJednotka	22340

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