About: Development of spray-dried chitosan microcarriers for nanoparticle delivery

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism. The design of chitosan microspheres for the encapsulation and release of nanoparticles has been considered. The composite microcarriers have been produced by spray drying and the effect of factors including the chitosan cross-linking ratio (using tri-polyphosphate as the cross-linking agent), nanoparticle loading in the polymer matrix and the internal structure of the microspheres (uniform dispersion of nanoparticles vs. core-shell structure) on the in vitro release kinetics have been systematically investigated. The antibacterial performance of the composite microspheres containing Ag nanoparticles has been evaluated against three different strains of bacteria in a suspension culture. The bioadhesive character of the chitosan carrier particles has lead to the formation of stable aggregates with the bacteria, which enhanced the antibacterial efficacy of the released nanoparticles through the contact mechanism. (en)
Title	Development of spray-dried chitosan microcarriers for nanoparticle delivery Development of spray-dried chitosan microcarriers for nanoparticle delivery (en)
skos:prefLabel	Development of spray-dried chitosan microcarriers for nanoparticle delivery Development of spray-dried chitosan microcarriers for nanoparticle delivery (en)
skos:notation	RIV/60461373:22340/13:43895516!RIV14-MSM-22340___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(MEB061108), S
http://linked.open...iv/cisloPeriodika	February 2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štěpánek, František Tokárová, Viola Kašpar, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	69187
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/13:43895516
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	E. coli; Diffusion; Nanoparticles; Spray drying; Chitosan (en)
http://linked.open.../riv/klicoveSlovo	Nanoparticles E. coli Spray drying Diffusion Chitosan
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[C3DDD1EDA5F2]
http://linked.open...i/riv/nazevZdroje	Powder Technology
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of chitosan based biomedical polymers with antibacterial properties
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	235
http://linked.open...iv/tvurceVysledku	Tokárová, Viola Štěpánek, František Kašpar, Ondřej Ulbrich, Pavel Knejzlík, Zdeněk
http://linked.open...ain/vavai/riv/wos	000316039400098
issn	0032-5910
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.powtec.2012.12.005
http://localhost/t...ganizacniJednotka	22340

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