About: Minimal reaction network for bistability in the MAPK signalling cascade.

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About: Minimal reaction network for bistability in the MAPK signalling cascade. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We used the stoichiometric networks analysis (SNA) to decompose a system involving activation of MAPKKK and first of the two double-phosphorylation cascades (which we call single-phosphorylation cascade model) into irreducible or elementary subnetworks (ESs). Then we identified those ESs that are potentially sources of nontrivial dynamical instabilities leading to bistability or oscillations. By using the classification system for chemical oscillators we further simplified the topology of the MAPK reaction network into the smallest network which still preserves bistability but does not allow for oscillations. This network can be examined analytically using both convex parametrization employed by the SNA and classical kinetic parameters (i.e., rate coefficients) to determine multiple steady states and their stability. Next we analyze the single-phosphorylation cascade model by using numerical continuation and determine what is the role of various subnetworks in forming the bistability. We used the stoichiometric networks analysis (SNA) to decompose a system involving activation of MAPKKK and first of the two double-phosphorylation cascades (which we call single-phosphorylation cascade model) into irreducible or elementary subnetworks (ESs). Then we identified those ESs that are potentially sources of nontrivial dynamical instabilities leading to bistability or oscillations. By using the classification system for chemical oscillators we further simplified the topology of the MAPK reaction network into the smallest network which still preserves bistability but does not allow for oscillations. This network can be examined analytically using both convex parametrization employed by the SNA and classical kinetic parameters (i.e., rate coefficients) to determine multiple steady states and their stability. Next we analyze the single-phosphorylation cascade model by using numerical continuation and determine what is the role of various subnetworks in forming the bistability. (en)
Title	Minimal reaction network for bistability in the MAPK signalling cascade. Minimal reaction network for bistability in the MAPK signalling cascade. (en)
skos:prefLabel	Minimal reaction network for bistability in the MAPK signalling cascade. Minimal reaction network for bistability in the MAPK signalling cascade. (en)
skos:notation	RIV/60461373:22340/12:43893663!RIV13-MSM-22340___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME10036)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hadač, Otto Přibyl, Michal Schreiber, Igor
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	150645
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/12:43893663
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bistability; stoichiometric network analysis; MAPK (en)
http://linked.open.../riv/klicoveSlovo	MAPK stoichiometric network analysis bistability
http://linked.open...ontrolniKodProRIV	[BEE239D925A3]
http://linked.open...v/mistoKonaniAkce	Pittsburgh
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	2012 AIChE Annual Meeting
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Přibyl, Michal Hadač, Otto Shvartsman, Stanislav Y.
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-10-28 (xsd:date)
number of pages	7 (xsd:int)
http://purl.org/ne...btex#hasPublisher	American Institute of Chemical Engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073-1
http://localhost/t...ganizacniJednotka	22340

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