About: Effects of oscillatory convective flow on chemical signal propagation in epithelia

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We study effects of convective transport on chemical signal propagation in a simple (single layer) epithelium by means of mathematical modeling. Oscillatory flow regimes were considered. In our model, we assume that the movement of an extracellular medium is affected by harmonically oscillating convective flow. The oscillatory flow can be induced by heart action or walking. We have carried out numerical simulations using Comsol Multiphysics 3.5. Our results suggest that the signal propagation velocity increases with increasing amplitude, if the convective velocity harmonically oscillates around the zero value. The dimensionless propagation velocity also depends on the period. At lower period regimes, the velocity is almost the same as in the case with stagnant extracellular medium (with zero convective velocity). With longer periods, the velocity becomes significantly higher. These results were confirmed by independent simulations based on the finite difference method. We study effects of convective transport on chemical signal propagation in a simple (single layer) epithelium by means of mathematical modeling. Oscillatory flow regimes were considered. In our model, we assume that the movement of an extracellular medium is affected by harmonically oscillating convective flow. The oscillatory flow can be induced by heart action or walking. We have carried out numerical simulations using Comsol Multiphysics 3.5. Our results suggest that the signal propagation velocity increases with increasing amplitude, if the convective velocity harmonically oscillates around the zero value. The dimensionless propagation velocity also depends on the period. At lower period regimes, the velocity is almost the same as in the case with stagnant extracellular medium (with zero convective velocity). With longer periods, the velocity becomes significantly higher. These results were confirmed by independent simulations based on the finite difference method. (en)
Title	Effects of oscillatory convective flow on chemical signal propagation in epithelia Effects of oscillatory convective flow on chemical signal propagation in epithelia (en)
skos:prefLabel	Effects of oscillatory convective flow on chemical signal propagation in epithelia Effects of oscillatory convective flow on chemical signal propagation in epithelia (en)
skos:notation	RIV/60461373:22340/12:43893661!RIV13-MSM-22340___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ME10036), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Přibyl, Michal Nebyla, Marek
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	133479
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/12:43893661
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epithelium; mathematical modeling; signal transmission; EGFR (en)
http://linked.open.../riv/klicoveSlovo	EGFR epithelium mathematical modeling signal transmission
http://linked.open...ontrolniKodProRIV	[8FA697A1533A]
http://linked.open...v/mistoKonaniAkce	Pittsburgh
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	2012 AIChE Annual Meeting
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Nebyla, Marek Přibyl, Michal
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-10-28 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	American Institute of Chemical Engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073-1
http://localhost/t...ganizacniJednotka	22340

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