About: Nitric Oxide Synthases Activation and Inhibition by Metallacarborane-Cluster-Based Isoform-Specific Affectors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A small-library of boron-cluster- and metallacarborane-cluster-based ligands was designed, prepared, and tested for isoform-selective activation or inhibition of the three nitric oxide synthase isoforms. On the basis of the concept of creating a hydrophobic analogue of a natural substrate, a stable and nontoxic basic boron cluster system, previously used for boron neutron capture therapy, was modified by the addition of positively charged moieties to its periphery, providing hydrophobic and nonclassical hydrogen, bonding interactions with the protein. Several of these compounds show efficacy for Inhibition of NO synthesis with differential effects on the various nitric oxide synthase isoforms. A small-library of boron-cluster- and metallacarborane-cluster-based ligands was designed, prepared, and tested for isoform-selective activation or inhibition of the three nitric oxide synthase isoforms. On the basis of the concept of creating a hydrophobic analogue of a natural substrate, a stable and nontoxic basic boron cluster system, previously used for boron neutron capture therapy, was modified by the addition of positively charged moieties to its periphery, providing hydrophobic and nonclassical hydrogen, bonding interactions with the protein. Several of these compounds show efficacy for Inhibition of NO synthesis with differential effects on the various nitric oxide synthase isoforms. (en)
Title	Nitric Oxide Synthases Activation and Inhibition by Metallacarborane-Cluster-Based Isoform-Specific Affectors Nitric Oxide Synthases Activation and Inhibition by Metallacarborane-Cluster-Based Isoform-Specific Affectors (en)
skos:prefLabel	Nitric Oxide Synthases Activation and Inhibition by Metallacarborane-Cluster-Based Isoform-Specific Affectors Nitric Oxide Synthases Activation and Inhibition by Metallacarborane-Cluster-Based Isoform-Specific Affectors (en)
skos:notation	RIV/60461373:22340/12:43893571!RIV13-GA0-22340___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA203/09/1311), P(GAP301/10/1426), P(GAP303/11/1291), P(IAAX00320901), Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kaplánek, Robert Král, Vladimír Rak, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	154246
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/12:43893571
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DIPEPTIDE AMIDES; ESCHERICHIA-COLI; MEDICINAL CHEMISTRY; HYDROPHOBIC PHARMACOPHORE; N-OMEGA-NITROARGININE; ELECTRON FLOW-THROUGH; AMIDE BOND PEPTIDOMIMETICS; DICARBA-CLOSO-DODECABORANE; HIGHLY SELECTIVE INHIBITORS; NEUTRON-CAPTURE THERAPY (en)
http://linked.open.../riv/klicoveSlovo	ESCHERICHIA-COLI HIGHLY SELECTIVE INHIBITORS AMIDE BOND PEPTIDOMIMETICS DICARBA-CLOSO-DODECABORANE DIPEPTIDE AMIDES ELECTRON FLOW-THROUGH HYDROPHOBIC PHARMACOPHORE MEDICINAL CHEMISTRY N-OMEGA-NITROARGININE NEUTRON-CAPTURE THERAPY
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3984835F230D]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Functionalized boron clusters as viral enzyme inhihitors Synthetic probes for recognition of tumor markers:applications for cell directed apoptosis and targeted photodynamic therapy Human cytochrome P450 oxidoreductase - effect of protein variant on structure, protein-protein interactions, chemical chaperones New types of ligands interfering with cancer cell communication as a new therapeutic strategy
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Grüner, Bohumír Kaplánek, Robert Král, Vladimír Rak, Jakub Martásek, Pavel Masters, BSS Panda, Satya Roman, Linda J
http://linked.open...ain/vavai/riv/wos	000311461500012
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0022-2623
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jm300805x
http://localhost/t...ganizacniJednotka	22340

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