About: MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mathematical model of signal transmission in epithelial tissue mediated by transmembrane epidermal growth factor receptor has been developed. The signal transmission is mediated by receptors from EGFR family and their ligands. These ligands can be transported by combination of convection and diffusion. Our model takes into account the influence of convection of extracellular medium. Here, we focus on single-layer of epithelial tissue. The developed model was analyzed using asymptotic and numerical methods. We observed nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities become much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either the velocity of the traveling front wave is slowed down or the traveling front wave can stop or reverse the direction of propagation. Mathematical model of signal transmission in epithelial tissue mediated by transmembrane epidermal growth factor receptor has been developed. The signal transmission is mediated by receptors from EGFR family and their ligands. These ligands can be transported by combination of convection and diffusion. Our model takes into account the influence of convection of extracellular medium. Here, we focus on single-layer of epithelial tissue. The developed model was analyzed using asymptotic and numerical methods. We observed nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities become much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either the velocity of the traveling front wave is slowed down or the traveling front wave can stop or reverse the direction of propagation. (en)
Title	MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA (en)
skos:prefLabel	MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA MATHEMATICAL MODEL OF SIGNAL PROPAGATION IN EPITHELIA (en)
skos:notation	RIV/60461373:22340/12:43893550!RIV13-MSM-22340___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ME10036), S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Přibyl, Michal Nebyla, Marek Schreiber, Igor
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	148719
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/12:43893550
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	signal transmission; convective flow; epithelia; EGFR; mathematical model (en)
http://linked.open.../riv/klicoveSlovo	EGFR mathematical model convective flow epithelia signal transmission
http://linked.open...ontrolniKodProRIV	[2FEEE5E1BCBE]
http://linked.open...v/mistoKonaniAkce	Tatranské Matliare, Slovakia
http://linked.open...i/riv/mistoVydani	Bratislava
http://linked.open...i/riv/nazevZdroje	39th International Conference of Slovak Society of Chemical Engineering
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Nebyla, Marek Přibyl, Michal
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-05-21 (xsd:date)
number of pages	9 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Slovak Society of Chemical Engineering
https://schema.org/isbn	978-80-89475-04-9
http://localhost/t...ganizacniJednotka	22340

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