About: Effects of Convective Transport on Chemical Signal Propagation in Epithelia

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0006349512001531
Description	We study effects of convective transport on a chemical front wave representing a signal propagation at a simple (single layer) epithelium by means of mathematical modeling. Plug flow and laminar flow regimes were considered. We observed a nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities becomes much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either velocity of the traveling front wave is slowed down or the traveling front wave can stop or reverse the direction of propagation. More importantly, chemical signal in epithelial systems influenced by the convective transport can propagate almost independently of the ligand-receptor binding constant in a broad range of this parameter. We study effects of convective transport on a chemical front wave representing a signal propagation at a simple (single layer) epithelium by means of mathematical modeling. Plug flow and laminar flow regimes were considered. We observed a nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities becomes much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either velocity of the traveling front wave is slowed down or the traveling front wave can stop or reverse the direction of propagation. More importantly, chemical signal in epithelial systems influenced by the convective transport can propagate almost independently of the ligand-receptor binding constant in a broad range of this parameter. (en)
Title	Effects of Convective Transport on Chemical Signal Propagation in Epithelia Effects of Convective Transport on Chemical Signal Propagation in Epithelia (en)
skos:prefLabel	Effects of Convective Transport on Chemical Signal Propagation in Epithelia Effects of Convective Transport on Chemical Signal Propagation in Epithelia (en)
skos:notation	RIV/60461373:22340/12:43893537!RIV13-GA0-22340___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GA203/09/2091), P(ME10036), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Přibyl, Michal Nebyla, Marek Schreiber, Igor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	133431
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/12:43893537
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	autocrine signaling; tyrosin kinase receptor; mathematical modeling; convective transport (en)
http://linked.open.../riv/klicoveSlovo	convective transport autocrine signaling tyrosin kinase receptor mathematical modeling
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6A9C5F207922]
http://linked.open...i/riv/nazevZdroje	BIOPHYSICAL JOURNAL
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional dynamics of heterogeneous-chemical and biochemical reaction systems with the use of reaction network analysis Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Nebyla, Marek Přibyl, Michal
http://linked.open...ain/vavai/riv/wos	000301280900005
issn	0006-3495
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bpj.2012.01.038
http://localhost/t...ganizacniJednotka	22340

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