About: Computational and experimental investigation of needle-shaped crystal breakage

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Needle-shaped crystals are a common occurrence in many pharmaceutical and fine chemicals processes. Even if the particle size distribution (PSD) obtained in a crystallization step can be controlled by the crystal growth kinetics and hydrodynamic conditions, further fluid-solid separation steps such as filtration, filter washing, drying, and subsequent solids handling can often lead to uncontrolled changes in the PSD due to breakage. In this contribution we present a combined computational and experimental methodology for determining the breakage kernel and the daughter distribution functions of needle-shaped crystals, and for population balance modeling of their breakage. A discrete element model (DEM) of needle-shaped particle breakage was first used in order to find out the appropriate types of the breakage kernel and the daughter distribution functions. A population balance model of breakage was then formulated and used in conjunction with experimental data in order to determine the material-specific parameters appearing in the breakage functions. Quantitative agreement between simulation and experiment has been obtained. (C) 2011 Elsevier B.V. All rights reserved. Needle-shaped crystals are a common occurrence in many pharmaceutical and fine chemicals processes. Even if the particle size distribution (PSD) obtained in a crystallization step can be controlled by the crystal growth kinetics and hydrodynamic conditions, further fluid-solid separation steps such as filtration, filter washing, drying, and subsequent solids handling can often lead to uncontrolled changes in the PSD due to breakage. In this contribution we present a combined computational and experimental methodology for determining the breakage kernel and the daughter distribution functions of needle-shaped crystals, and for population balance modeling of their breakage. A discrete element model (DEM) of needle-shaped particle breakage was first used in order to find out the appropriate types of the breakage kernel and the daughter distribution functions. A population balance model of breakage was then formulated and used in conjunction with experimental data in order to determine the material-specific parameters appearing in the breakage functions. Quantitative agreement between simulation and experiment has been obtained. (C) 2011 Elsevier B.V. All rights reserved. (en)
Title	Computational and experimental investigation of needle-shaped crystal breakage Computational and experimental investigation of needle-shaped crystal breakage (en)
skos:prefLabel	Computational and experimental investigation of needle-shaped crystal breakage Computational and experimental investigation of needle-shaped crystal breakage (en)
skos:notation	RIV/60461373:22340/11:43892337!RIV12-MSM-22340___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP104/08/P389), Z(MSM6046137306)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štěpánek, František Grof, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	191498
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/11:43892337
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Breakage kernel; Daughter length distribution; Fragmentation; Population balance modeling; DEM (en)
http://linked.open.../riv/klicoveSlovo	Breakage kernel DEM Daughter length distribution Fragmentation Population balance modeling
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[53709A870BDE]
http://linked.open...i/riv/nazevZdroje	International Journal Pharm.
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Mesoscopic modeling of complex materials formation
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	407
http://linked.open...iv/tvurceVysledku	Grof, Zdeněk Rajniak, Pavol Schoellhammer, Carl Štěpánek, František
http://linked.open...ain/vavai/riv/wos	000288777400002
http://linked.open...n/vavai/riv/zamer	Reakčně-transportní chemicko-inženýrské systémy a jejich dynamické chování, modelování a řízení chemických a biotechnologických procesů
issn	0378-5173
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpharm.2010.12.031
http://localhost/t...ganizacniJednotka	22340

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