About: Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A computer model was developed with the objective of modelling pharmaceutical tablet dissolution with non-swelling excipients. The model, which allows the explicit description of the tablets heterogeneous microstructure, was verified using Fourier Transform Infrared (FTIR) spectroscopic imaging and UV-visible spectroscopy. Two parametric studies were conducted using the model for binary tablets. One investigated the effect of particle size and tablet composition on component release times and the other studied the effect of changing the diffusivity and solubility of one component on the release times of both. Tablets containing Polyethylene Glycol (PEG) 4000 and nicotinamide were used in the experiments. Physical properties of pure components were obtained from literature and also experiments using tablets containing 100% and 10% (w/w) nicotinamide. The model was then used to predict the dissolution of a tablet containing 40% (w/w) nicotinamide which matched the experiment with a mean squared error of 0.08%. A computer model was developed with the objective of modelling pharmaceutical tablet dissolution with non-swelling excipients. The model, which allows the explicit description of the tablets heterogeneous microstructure, was verified using Fourier Transform Infrared (FTIR) spectroscopic imaging and UV-visible spectroscopy. Two parametric studies were conducted using the model for binary tablets. One investigated the effect of particle size and tablet composition on component release times and the other studied the effect of changing the diffusivity and solubility of one component on the release times of both. Tablets containing Polyethylene Glycol (PEG) 4000 and nicotinamide were used in the experiments. Physical properties of pure components were obtained from literature and also experiments using tablets containing 100% and 10% (w/w) nicotinamide. The model was then used to predict the dissolution of a tablet containing 40% (w/w) nicotinamide which matched the experiment with a mean squared error of 0.08%. (en)
Title	Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution (en)
skos:prefLabel	Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution (en)
skos:notation	RIV/60461373:22340/11:43892159!RIV12-MSM-22340___
http://linked.open...avai/riv/aktivita	R
http://linked.open...avai/riv/aktivity	R
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štěpánek, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	212375
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/11:43892159
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Simulation; Pharmaceuticals; Mathematical modelling; Imaging; Dissolution; ATR FT-IR spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	Pharmaceuticals Simulation Imaging Mathematical modelling ATR FT-IR spectroscopy Dissolution
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C46DC84C0F39]
http://linked.open...i/riv/nazevZdroje	COMPUTERS & CHEMICAL ENGINEERING
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Kazarian, Sergei G. Kimber, James A. Štěpánek, František
http://linked.open...ain/vavai/riv/wos	000292093700015
issn	0098-1354
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.compchemeng.2010.07.008
http://localhost/t...ganizacniJednotka	22340

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