About: A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation

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About: A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background and Aims: AGEs (advanced glycation end products) are involved in the pathogenesis of vascular damage and progression of chronic kidney diseases. They are detoxified by the glyoxalase (GLO) system. The aim of the study was to test whether A419C polymorphism of GLO I gene is associated with the outcome of kidney transplantation. Methods: A419C polymorphism of the GLO I gene was assessed in 145 renal transplant recipients and its relationship to histological changes in 12 months protocol kidney graft biopsy and renal function was examined. Results: Genotype frequencies of the studied polymorphism corresponded to the expected frequencies according to Hardy-Weinberg equilibrium. No significant differences among allelic and genotype frequencies among patients with normal histological findings, interstitial fibrosis/tubular atrophy and subclinical rejection and renal parameters were found. However, a trend towards lower levels of serum creatinine and proteinuria was observed in patients with C Background and Aims: AGEs (advanced glycation end products) are involved in the pathogenesis of vascular damage and progression of chronic kidney diseases. They are detoxified by the glyoxalase (GLO) system. The aim of the study was to test whether A419C polymorphism of GLO I gene is associated with the outcome of kidney transplantation. Methods: A419C polymorphism of the GLO I gene was assessed in 145 renal transplant recipients and its relationship to histological changes in 12 months protocol kidney graft biopsy and renal function was examined. Results: Genotype frequencies of the studied polymorphism corresponded to the expected frequencies according to Hardy-Weinberg equilibrium. No significant differences among allelic and genotype frequencies among patients with normal histological findings, interstitial fibrosis/tubular atrophy and subclinical rejection and renal parameters were found. However, a trend towards lower levels of serum creatinine and proteinuria was observed in patients with C (en)
Title	A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation (en)
skos:prefLabel	A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation A419C polymorphism of glyoxalase I gene: renal function and histological finding at 12 months after renal transplantation (en)
skos:notation	RIV/60461373:22340/10:00023496!RIV11-MSM-22340___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Mestek, Oto
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	248327
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/10:00023496
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Biopsy; Interstitial Fibrosis and Tubular Atrophy; Glyoxalase I; Kidney transplantation; Polymorphism; Receptor for Advanced Glycation End Products (en)
http://linked.open.../riv/klicoveSlovo	Interstitial Fibrosis and Tubular Atrophy Receptor for Advanced Glycation End Products Glyoxalase I Polymorphism Kidney transplantation Biopsy
http://linked.open...odStatuVydavatele	IR - Íránská islámská republika
http://linked.open...ontrolniKodProRIV	[642AAAE4EF7A]
http://linked.open...i/riv/nazevZdroje	International Journal of Nephrology and Urology
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Mestek, Oto Kalousová, M. Zima, T. Viklický, O. Brabcová, I. Slatinská, J. Germanová, A. Jáchymová, M. Matl, I.
issn	2008-4684
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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