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rdf:type
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Description
| - Objectives: The receptor for advanced glycation end-products (RAGE) takes part in the pathogenesis ofmany diseases, including diabetes mellitus and cancer. AGE-precursors are detoxified by glyoxalase (GLO).sRAGE, soluble RAGE, is an inhibitor of pathological effects mediated via RAGE. The aim was to study sRAGE and polymorphisms of RAGE (AGER) and GLO genes in patients with pancreas cancer (PC). Design and Methods: The studied group consisted of 51 patients with PC (34 with impaired glucose tolerance?IGT, 17without IGT), 34 type 2DMand 154 controls. For genetic analysis, the number of patients was increased to 170. Serum sRAGE was measured by ELISA and all polymorphisms (RAGE -429T/C, -374T/A, 2184A/G, Gly82Ser and GLO A419C) were determined by PCR-RFLP and confirmed by sequencing. Results: Soluble RAGE is decreased in patientswith PC compared to atients with DM and controls (975?532 vs. 1416?868 vs. 1723?643 pg/mL, p< 0.001). Patients with PC and IGT have lower sRAGE levels compared to pati
- Objectives: The receptor for advanced glycation end-products (RAGE) takes part in the pathogenesis ofmany diseases, including diabetes mellitus and cancer. AGE-precursors are detoxified by glyoxalase (GLO).sRAGE, soluble RAGE, is an inhibitor of pathological effects mediated via RAGE. The aim was to study sRAGE and polymorphisms of RAGE (AGER) and GLO genes in patients with pancreas cancer (PC). Design and Methods: The studied group consisted of 51 patients with PC (34 with impaired glucose tolerance?IGT, 17without IGT), 34 type 2DMand 154 controls. For genetic analysis, the number of patients was increased to 170. Serum sRAGE was measured by ELISA and all polymorphisms (RAGE -429T/C, -374T/A, 2184A/G, Gly82Ser and GLO A419C) were determined by PCR-RFLP and confirmed by sequencing. Results: Soluble RAGE is decreased in patientswith PC compared to atients with DM and controls (975?532 vs. 1416?868 vs. 1723?643 pg/mL, p< 0.001). Patients with PC and IGT have lower sRAGE levels compared to pati (en)
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Title
| - Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer
- Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer (en)
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skos:prefLabel
| - Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer
- Soluble receptor for advanced glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer (en)
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skos:notation
| - RIV/60461373:22340/10:00023479!RIV11-MSM-22340___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/10:00023479
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Cancer; Diabetes mellitus; Glyoxalase; Pancreas; Polymorphism; RAGE; Receptor for advanced glycation end products; Soluble receptor for advanced glycation end products sRAGE (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Mestek, Oto
- Kalousová, M.
- Zima, T.
- Jáchymová, M.
- Krechler, T.
- Žák, A.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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