About: Stoichiometric network analysis of MAPK cascade

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Mitogen Activated Protein Kinase (MAPK) cascade is a highly conserved series of three protein kinases that conducts information signals to operate diverse biological processes. A parameter model of signal transduction produce nonlinear behaviour like bistability and oscillations. The reaction mechanism of MAPK cascade is composed from twelve biochemical reactions creating a larger chemical network. Methods of stoichiometric network analysis (SNA) are used to separate the entire network into irreducible subnetworks and then apply linear stability analysis to reveal potential dynamical instabilities. Finally, unstable subnetwork that evokes oscillatory behaviour has been identified. The Mitogen Activated Protein Kinase (MAPK) cascade is a highly conserved series of three protein kinases that conducts information signals to operate diverse biological processes. A parameter model of signal transduction produce nonlinear behaviour like bistability and oscillations. The reaction mechanism of MAPK cascade is composed from twelve biochemical reactions creating a larger chemical network. Methods of stoichiometric network analysis (SNA) are used to separate the entire network into irreducible subnetworks and then apply linear stability analysis to reveal potential dynamical instabilities. Finally, unstable subnetwork that evokes oscillatory behaviour has been identified. (en)
Title	Stoichiometric network analysis of MAPK cascade Stoichiometric network analysis of MAPK cascade (en)
skos:prefLabel	Stoichiometric network analysis of MAPK cascade Stoichiometric network analysis of MAPK cascade (en)
skos:notation	RIV/60461373:22340/10:00023260!RIV11-GA0-22340___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA203/09/2091), P(GD104/08/H055), P(ME10036), S, Z(MSM6046137306)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hadač, Otto Nevoral, Vladislav Přibyl, Michal Schreiber, Igor Červenka, Petr
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	290162
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/10:00023260
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAPK cascade; stoichiometric network analysis; oscillations; autocatalysis; biological network (en)
http://linked.open.../riv/klicoveSlovo	oscillations autocatalysis stoichiometric network analysis MAPK cascade biological network
http://linked.open...ontrolniKodProRIV	[030A18E141E3]
http://linked.open...v/mistoKonaniAkce	Litomyšl
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Reakční a transportní jevy IV
http://linked.open...in/vavai/riv/obor	CI
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional dynamics of heterogeneous-chemical and biochemical reaction systems with the use of reaction network analysis Transport and reaction processes in complex multiphase systems Effects of convective transport on chemical signal propagation in living tissues
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Schreiber, Igor Přibyl, Michal Hadač, Otto Nevoral, Vladislav Červenka, Petr
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2010-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Reakčně-transportní chemicko-inženýrské systémy a jejich dynamické chování, modelování a řízení chemických a biotechnologických procesů
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Vysoká škola chemicko-technologická v Praze
https://schema.org/isbn	978-80-7080-761-3
http://localhost/t...ganizacniJednotka	22340

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