About: Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients

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About: Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. (en)
Title	Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients (en)
skos:prefLabel	Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients (en)
skos:notation	RIV/60461373:22340/10:00023202!RIV11-GA0-22340___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA203/09/1311), P(KAN200100801), P(LC512)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kaplánek, Robert Král, Vladimír Rak, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	288520
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/10:00023202
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant (en)
http://linked.open.../riv/klicoveSlovo	Cyclodextrin Surfactant Solubilization Metallacarborane Cobalt bis(dicarbollide) Deaggregation Excipient Surfactant Cobalt bis(dicarbollide)
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[08D14F6551F5]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthetic probes for recognition of tumor markers:applications for cell directed apoptosis and targeted photodynamic therapy Bioactive Biocompatible Surfaces and Novel Nanostructured Composites for Applications to Medicine and Drug Delivery Center for biomolecules and complex molecular systems
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kaplánek, Robert Král, Vladimír Rak, Jakub
http://linked.open...ain/vavai/riv/wos	000273783800056
issn	0960-894X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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