About: A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients

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About: A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Advanced glycation end products (AGEs) take part in the pathogenesis of vascular, diabetic, and uremic complications. Their precursors are detoxified by the glyoxalase system. Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) patients. A419C SNP, several laboratory parameters including soluble receptor for AGEs (sRAGE), and clinical data were studied in 214 HD patients and 89 controls. Allelic and genotypic frequencies did not differ between HD patients and controls. A419C SNP was significantly linked with serum sRAGE, which sensitively reflects the AGE burden of the organism (3986 +/- 1638 pg/mL in the CC variant versus 3277 +/- 1398 pg/mL in the AC variant and 3297 +/- 1445 pg/mL in the AA variant, P < 0.01). In the CC variant, significantly higher prevalence of cardiovascular disease and peripheral vascular disease was found, while the prevalence of hypertension, diabetes mellitus, and dyslipidemia did not differ between genotyp Advanced glycation end products (AGEs) take part in the pathogenesis of vascular, diabetic, and uremic complications. Their precursors are detoxified by the glyoxalase system. Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) patients. A419C SNP, several laboratory parameters including soluble receptor for AGEs (sRAGE), and clinical data were studied in 214 HD patients and 89 controls. Allelic and genotypic frequencies did not differ between HD patients and controls. A419C SNP was significantly linked with serum sRAGE, which sensitively reflects the AGE burden of the organism (3986 +/- 1638 pg/mL in the CC variant versus 3277 +/- 1398 pg/mL in the AC variant and 3297 +/- 1445 pg/mL in the AA variant, P < 0.01). In the CC variant, significantly higher prevalence of cardiovascular disease and peripheral vascular disease was found, while the prevalence of hypertension, diabetes mellitus, and dyslipidemia did not differ between genotyp (en)
Title	A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients (en)
skos:prefLabel	A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients (en)
skos:notation	RIV/60461373:22340/08:00021382!RIV10-MSM-22340___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	1126
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Mestek, Oto
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	357519
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/08:00021382
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	advanced glycation end products; cardiovascular; glyoxalase; hemodialysis; polymorphisms; sRAGE (en)
http://linked.open.../riv/klicoveSlovo	advanced glycation end products glyoxalase hemodialysis polymorphisms sRAGE cardiovascular
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9BE5141AE7A5]
http://linked.open...i/riv/nazevZdroje	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Jáchymová, Marie Mestek, Oto Zima, Tomáš Kalousova, Marta Germanova, Alexandra Tesák, Vladimír
http://linked.open...ain/vavai/riv/wos	000255833300053
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění
issn	0077-8923
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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