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| rdf:type
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| Description
| - The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t
- The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t (en)
- Práce popisuje experimentální studii vlivu složení a mikrostruktury granulí obsahujících dva typy primárních částic a pojivo na rychost vylučování složek a celkovou rychlost rozpouštění. Granule byly vytvořeny ve fluidním granulátoru a rychlost rozpouštění byla studována konduktometricky. Poprvé byla experimentálně ověřena existence maxima rozpouštěcí rychlosti v závislosti na obsahu aktivní složky v granuli. (cs)
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| Title
| - The evolution of microstructure in three-component granulation and its effect on dissolution
- Vznik mikrostruktury ve třísložkové granulaci a její vliv na rozpouštění (cs)
- The evolution of microstructure in three-component granulation and its effect on dissolution (en)
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| skos:prefLabel
| - The evolution of microstructure in three-component granulation and its effect on dissolution
- Vznik mikrostruktury ve třísložkové granulaci a její vliv na rozpouštění (cs)
- The evolution of microstructure in three-component granulation and its effect on dissolution (en)
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| skos:notation
| - RIV/60461373:22340/08:00020747!RIV09-MSM-22340___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/08:00020747
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - dissolution; granulation; melt binder; microstructure; particle size; product design (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Particulate Science and Technology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Štěpánek, František
- Ansari, Mansoor
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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