About: The effect of granule microstructure on dissolution rate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have
  • The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have (en)
  • V této práci je popsána studie vlivu porozity granulí a obsahu a typu pojiva na rychlost jejich rozpouštění. Byly studovány granule dvojího typu ? s pojivem dodávaným jako tavenina a jako roztok. Je ukázáno, že pro danou kombinaci primárních částic a materiálu pojiva je rozhodujícím parametrem pro rozpouštění porozita granulí. (cs)
Title
  • The effect of granule microstructure on dissolution rate
  • Vliv mikrostruktury granulí na rychlost rozpouštění (cs)
  • The effect of granule microstructure on dissolution rate (en)
skos:prefLabel
  • The effect of granule microstructure on dissolution rate
  • Vliv mikrostruktury granulí na rychlost rozpouštění (cs)
  • The effect of granule microstructure on dissolution rate (en)
skos:notation
  • RIV/60461373:22340/08:00020745!RIV09-MSM-22340___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 365100
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22340/08:00020745
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Granulation; Porosity; Microstructure; Dissolution; Computer simulation; Product design (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [6FF30D24B6D1]
http://linked.open...i/riv/nazevZdroje
  • Powder Technology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 181
http://linked.open...iv/tvurceVysledku
  • Štěpánek, František
  • Ansari, Mansoor
http://linked.open...ain/vavai/riv/wos
  • 000253190200003
issn
  • 0032-5910
number of pages
http://localhost/t...ganizacniJednotka
  • 22340
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software