About: Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Práce popisuje syntézu a detailní spektroskopickou charakterizaci metallakarboranových konjugátů tetrafenylporfyrinu. Je vysvětlena závislost fenoménu molekulární asociace konjugátů na pH roztoku a prokázána inhibice HIV proteasy. (cs) Tetraphenylporphyrin conjugates with four (PB4) and one (PB1) cobalt(III)bis(1,2-dicarbollide) substituents were synthesized. The physico-chemical and photophysical properties as well as inhibition of HIV-1 protease are described. In methanol, both PB4 and PB1 are monomeric and form the triplet states and singlet oxygen after excitation. We observed protonation of the triplet states and only a small decrease of quantum yields of the singlet oxygen formation (17 % for PB4 and 13% for PB1) as compared with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin. On the contrary, no singlet oxygen was detected in aqueous solutions due to strong aggregation. Light scattering and AFM measurements show that the behavior of aggregates in aqueous solutions is fairly complex and depends on pH, concentration and aging. The aggregation in neutral solutions starts with the formation of spherical species. In acidic solutions, an extended aggregation occurs due to slow protonation of the porphyrin pyrrole nitrogens. Both P Tetraphenylporphyrin conjugates with four (PB4) and one (PB1) cobalt(III)bis(1,2-dicarbollide) substituents were synthesized. The physico-chemical and photophysical properties as well as inhibition of HIV-1 protease are described. In methanol, both PB4 and PB1 are monomeric and form the triplet states and singlet oxygen after excitation. We observed protonation of the triplet states and only a small decrease of quantum yields of the singlet oxygen formation (17 % for PB4 and 13% for PB1) as compared with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin. On the contrary, no singlet oxygen was detected in aqueous solutions due to strong aggregation. Light scattering and AFM measurements show that the behavior of aggregates in aqueous solutions is fairly complex and depends on pH, concentration and aging. The aggregation in neutral solutions starts with the formation of spherical species. In acidic solutions, an extended aggregation occurs due to slow protonation of the porphyrin pyrrole nitrogens. Both P (en)
Title	Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease (en) Konjugáty kobalt(3+) bis(1,2-dikarbolidu) s tetrafenylporfyrinem: od vlastností roztoků k inhibici HIV proteasy. (cs)
skos:prefLabel	Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease (en) Konjugáty kobalt(3+) bis(1,2-dikarbolidu) s tetrafenylporfyrinem: od vlastností roztoků k inhibici HIV proteasy. (cs)
skos:notation	RIV/60461373:22340/07:00020926!RIV09-MSM-22340___
http://linked.open...avai/riv/aktivita	P R S Z
http://linked.open...avai/riv/aktivity	P(1M0508), P(GA203/04/0426), P(GA203/04/0490), P(GA203/07/1424), P(KAN100500652), R, S, Z(AV0Z40320502), Z(AV0Z40400503), Z(AV0Z40550506), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Cígler, Petr Král, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoká škola chemicko-technologická v Praze / Fakulta chemicko-inženýrská
http://linked.open...dnocenehoVysledku	454901
http://linked.open...ai/riv/idVysledku	RIV/60461373:22340/07:00020926
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	porphyrin; metallacarborane; cobalt(III) bis(1,2-dicarbollide); HIV protease; association (en)
http://linked.open.../riv/klicoveSlovo	metallacarborane association porphyrin HIV protease 2-dicarbollide) cobalt(III) bis(1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7C51E9587AC4]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF PHYSICAL CHEMISTRY B
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics Heterogeneous and hybrid nanocomposite materials for solar cells Design and characterization of new photosensitizers and investigation of their interaction with target biological molecules Stimuli-responsive self-organized nanostructures based on novel polyelectrolyte architectures Self-assembled porphyrin nanostructures
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	111
http://linked.open...iv/tvurceVysledku	Cígler, Petr Král, Vladimír Kubát, Pavel Kožíšek, Milan Lang, Kamil Matějíček, Pavel Zelinger, Zdeněk Janda, Pavel Procházka, Karel
http://linked.open...ain/vavai/riv/wos	000245954800034
http://linked.open...n/vavai/riv/zamer	Design, syntéza a charakterizace klastrů, kompozitů, komplexů a dalších sloučenin na bázi anorganických látek; mechanismy a kinetika jejich interakcí Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1520-6106
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	22340

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