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| Description
| - V představeném studiu byly sledované fotosensibilní vlastnosti dvou nových mono- a bis-cyclodextrin tetrakis(pentafluorofenyl) porfyrinových derivátů na kulturách nádorových buněk a na nádoru prsní žlázy 4T1 transplantovaného pod kůži BALB/c myši. Obě studované látky v experimentech in vitro prokázaly lokalizace v lysosomech buněčných kultur a indukovaly smrt buněk spouštěním apoptosy. Mono-cyclodextrin porfyrinový derivát, P(b-CD)1, projevoval silnější fotodynamický efekt in vitro než bis-cyclodextrinový derivat P(b-CD)2. Ale v experimentech in vivo P(b-CD)2 ukázal rychlejší lokalizace v nádorové tkáni s maximální obsahem už za 6 hodin po aplikace a silnější protinádorovou aktivitu na rozdíl od P(b-CD)1 z pomalejší lokalizace. (cs)
- In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis(pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing subcutaneously transplanted syngeneic mouse mammary carcinoma, 4T1. Both studied sensitizers were localized mainly into lysosomes and were found to induce cells death by triggering apoptosis in human leukemic cells HL-60. In 4T1 and other cell lines both apoptotic and necrotic modes of cell death occurred dependently on drug and light doses. Mono-cyclodextrin porphyrin derivative, P(b-CD)1, exhibited stronger in vitro photodynamic efficacy than bis-cyclodextrin derivative, P(b-CD)2. However, when their efficacy was evaluated in vivo, P(b-CD)2 displayed faster tumor uptake with maximal accumulation 6 h after application leading to complete and prolonged elimination of subcutaneous tumors within 3 days after irradiation (100 J/cm2). In contrast P(b-CD)1 uptake was slower (48 h) and reduction of tu
- In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis(pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing subcutaneously transplanted syngeneic mouse mammary carcinoma, 4T1. Both studied sensitizers were localized mainly into lysosomes and were found to induce cells death by triggering apoptosis in human leukemic cells HL-60. In 4T1 and other cell lines both apoptotic and necrotic modes of cell death occurred dependently on drug and light doses. Mono-cyclodextrin porphyrin derivative, P(b-CD)1, exhibited stronger in vitro photodynamic efficacy than bis-cyclodextrin derivative, P(b-CD)2. However, when their efficacy was evaluated in vivo, P(b-CD)2 displayed faster tumor uptake with maximal accumulation 6 h after application leading to complete and prolonged elimination of subcutaneous tumors within 3 days after irradiation (100 J/cm2). In contrast P(b-CD)1 uptake was slower (48 h) and reduction of tu (en)
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| Title
| - Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo
- Nové porfyrinové conjugaty s fotodynamickým protinádorovým efektem: účinnost mono- a bis-b-cyclodextrinových derivátů v in vivo a in vitro studiu (cs)
- Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo (en)
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| skos:prefLabel
| - Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo
- Nové porfyrinové conjugaty s fotodynamickým protinádorovým efektem: účinnost mono- a bis-b-cyclodextrinových derivátů v in vivo a in vitro studiu (cs)
- Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo (en)
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| skos:notation
| - RIV/60461373:22340/06:00016680!RIV07-MSM-22340___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA301/04/1315), Z(MSM6046137307)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60461373:22340/06:00016680
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - porphyrin; mono- and bis-b-cyclodextrin derivatives; photodynamic antitumor effect (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Photochemistry and Photobiology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Král, Vladimír
- Poučková, P.
- Synytsya, Alla
- Dvořák, M.
- Králová, J.
- Koc, M.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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