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Description
  • Mathematical modeling of electrokinetic transport processes and antigen-antibody interactions in a microfluidic biosensor for heterogeneous immunoassay is described. Two mathematical models of externally controlled electroosmotic transport are constructed - the slip model based on Helmholtz-Smoluchowski approximation and the non-slip model based on the use of Poisson equation. It was found that the use of the slip model is restricted by concentration of the carrier electrolyte and dimensions of the system. The antigen-antibody interaction cannot be described by the slip model. Dynamics of the heterogeneous immunoassay in the proposed biosensor was also studied. Human-IgG-Protein A was used as model system. Parametric studies revealed strong sensitivity of the biosensor to the antibody charge number and to the character of surface heterogeneity in the position of immobilized antigen. This sensitivity can be one of the reasons why the practical applications of heterogeneous protein chips are still rare.
  • Mathematical modeling of electrokinetic transport processes and antigen-antibody interactions in a microfluidic biosensor for heterogeneous immunoassay is described. Two mathematical models of externally controlled electroosmotic transport are constructed - the slip model based on Helmholtz-Smoluchowski approximation and the non-slip model based on the use of Poisson equation. It was found that the use of the slip model is restricted by concentration of the carrier electrolyte and dimensions of the system. The antigen-antibody interaction cannot be described by the slip model. Dynamics of the heterogeneous immunoassay in the proposed biosensor was also studied. Human-IgG-Protein A was used as model system. Parametric studies revealed strong sensitivity of the biosensor to the antibody charge number and to the character of surface heterogeneity in the position of immobilized antigen. This sensitivity can be one of the reasons why the practical applications of heterogeneous protein chips are still rare. (en)
  • Matematické modelování elektrokinetických transportních procesů a interakce antigen-protilátka v mikrofluidním biosenzoru pro heterogenní imunoanalýzu jsou popsány. Dva matematické modely externě řízeného elektrokinetického transportu jsou vytvořeny - slip model založený na Helmholtz-Smoluchowského aproximaci a neskluzový model založený na Poissonově rovnici. Parametrické studie odhalily velkou citlivost biosenzoru k nábojovému číslu protilátky a charakteru povrchové heterogenity v místě imobilizovaného antigenu. (cs)
Title
  • Modeling reaction-transport processes in a microcapillary biosensor for detection of human IgG
  • Modelování reakčně transportních procesů v mikrokapilárním biosenzoru pro detekci lidských IgG (cs)
  • Modeling reaction-transport processes in a microcapillary biosensor for detection of human IgG (en)
skos:prefLabel
  • Modeling reaction-transport processes in a microcapillary biosensor for detection of human IgG
  • Modelování reakčně transportních procesů v mikrokapilárním biosenzoru pro detekci lidských IgG (cs)
  • Modeling reaction-transport processes in a microcapillary biosensor for detection of human IgG (en)
skos:notation
  • RIV/60461373:22340/06:00016652!RIV07-MSM-22340___
http://linked.open.../vavai/riv/strany
  • 1660-1663
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP104/03/D006), Z(MSM6046137306)
http://linked.open...iv/cisloPeriodika
  • 4-9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 486185
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22340/06:00016652
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MICROFLUIDIC DEVICES; ELECTROOSMOTIC FLOW; MicroCAPILLARIES; microSYSTEMS; electric FIELD; microCHIPS (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [15F29E8DD617]
http://linked.open...i/riv/nazevZdroje
  • Microelectronic Engineering
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 83
http://linked.open...iv/tvurceVysledku
  • Šnita, Dalimil
  • Přibyl, Michal
  • Marek, Miloš
  • Knápková, Veronika
http://linked.open...n/vavai/riv/zamer
issn
  • 0167-9317
number of pages
http://localhost/t...ganizacniJednotka
  • 22340
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